PI3K Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

p120γ

PI3K Inhibitors, Activators & Modulators

Product Name	PI3Kα	PI3Kβ	PI3Kγ	PI3Kδ	PI3KC2α	PI3KC2β	PI3KC2γ	Vps34	PI3K	PI3KC3	p120γ	Purity
3-Methyladenine			PtdIns3Kγ, IC₅₀: 60 μM (Cell Assay)					Vps34, IC₅₀: 25 μM (Cell Assay)				99.91%
LY294002	p110α, IC₅₀: 0.5 μM	p110β, IC₅₀: 0.97 μM		p110δ, IC₅₀: 0.57 μM								99.95%
Quercetin		PI3Kβ, IC₅₀: 5.4 μM	PI3Kγ, IC₅₀: 3 μM	PI3Kδ, IC₅₀: 2.4 μM								98.45%
Alpelisib	p110α, IC₅₀: 5 nM p110α-H1047R, IC₅₀: 4 nM p110α-E545K, IC₅₀: 4 nM	p110β, IC₅₀: 1200 nM	p110γ, IC₅₀: 250 nM	p110δ, IC₅₀: 290 nM								99.95%
740 Y-P									PI3K			99.67%
Gedatolisib	PI3Kα, IC₅₀: 0.4 nM PI3Kα-H1047R, IC₅₀: 0.6 nM PI3Kα-E545K, IC₅₀: 0.6 nM	PI3Kβ, IC₅₀: 6 nM	PI3Kγ, IC₅₀: 5.4 nM	PI3Kδ, IC₅₀: 6 nM								99.68%
MTX-531	PI3Kα, IC₅₀: 6.4 nM	PI3Kβ, IC₅₀: 233 nM	PI3Kγ, IC₅₀: 8.3 nM	PI3Kδ, IC₅₀: 1.1 nM								99.08%
Wortmannin									PI3K, IC₅₀: 3 nM			99.86%
AZD-7648			PI3Kγ, IC₅₀: 1.37 μM									99.86%
Idelalisib	p110α, IC₅₀: 820 nM	p110β, IC₅₀: 565 nM	p110γ, IC₅₀: 89 nM	p110δ, IC₅₀: 2.5 nM				hVps34, IC₅₀: 978 nM				99.78%
Pictilisib	p110α, IC₅₀: 3 nM p110α-H1047R, IC₅₀: 3 nM p110α-E545K, IC₅₀: 3 nM	p110β, IC₅₀: 33 nM	p110γ, IC₅₀: 75 nM	p110δ, IC₅₀: 3 nM								99.80%
Inavolisib	PI3Kα, IC₅₀: 0.038 nM											99.96%
Buparlisib	p110α, IC₅₀: 52 nM p110α-H1047R, IC₅₀: 58 nM p110α-E545K, IC₅₀: 99 nM	p110β, IC₅₀: 166 nM	p110γ, IC₅₀: 262 nM	p110δ, IC₅₀: 116 nM				Vps34, IC₅₀: 2.4 μM				99.90%
α-Linolenic acid									PI3K			99.92%
Copanlisib	PI3Kα, IC₅₀: 0.5 nM	PI3Kβ, IC₅₀: 3.7 nM	PI3Kγ, IC₅₀: 6.4 nM	PI3Kδ, IC₅₀: 0.7 nM								99.50%
Dactolisib	p110α, IC₅₀: 4 nM p110α-H1047R, IC₅₀: 4.6 nM p110α-E545K, IC₅₀: 5.7 nM	p110β, IC₅₀: 75 nM	p110γ, IC₅₀: 5 nM	p110δ, IC₅₀: 7 nM								99.94%
Duvelisib	p110α, IC₅₀: 1602 nM	p110β, IC₅₀: 85 nM	p110γ, IC₅₀: 27.4 nM	p110δ, IC₅₀: 2.5 nM								99.88%
SAR405								Vps34, IC₅₀: 1.2 nM Vps34, Kd: 1.5 nM				99.49%
Eganelisib	PI3Kα, IC₅₀: 3.2 μM	PI3Kβ, IC₅₀: 3.5 μM	PI3Kγ, IC₅₀: 16 nM									99.69%
Recilisib									PI3K			99.14%
YM-201636	p110α, IC₅₀: 3.3 μM											98.06%
Isorhamnetin									PI3-K			99.94%
PI-103	p110α, IC₅₀: 8 nM	p110β, IC₅₀: 88 nM	p110γ, IC₅₀: 150 nM	p110δ, IC₅₀: 48 nM	PI3KC2α, IC₅₀: 1 μM	PI3KC2β, IC₅₀: 26 nM		hsVPS34, IC₅₀: 2.3 μM				98.93%
Omipalisib	p110α, Ki: 0.019 nM p110α-H1047R, Ki: 0.009 nM p110α-E545K, Ki: 0.008 nM p110α-E542K, Ki: 0.008 nM	p110β, Ki: 0.13 nM	p110γ, Ki: 0.06 nM	p110δ, Ki: 0.024 nM								99.93%
Copanlisib dihydrochloride	PI3Kα, IC₅₀: 0.5 nM	PI3Kβ, IC₅₀: 3.7 nM	PI3Kγ, IC₅₀: 6.4 nM	PI3Kδ, IC₅₀: 0.7 nM								99.55%
Taselisib	PI3Kα, Ki: 0.29 nM	PI3Kβ, Ki: 9.1 nM	PI3Kγ, Ki: 0.97 nM	PI3Kδ, Ki: 0.12 nM								99.75%
Fimepinostat	PI3Kα, IC₅₀: 19 nM	PI3Kβ, IC₅₀: 54 nM	PI3Kγ, IC₅₀: 311 nM	PI3Kδ, IC₅₀: 39 nM								99.95%
hSMG-1 inhibitor 11j	PI3Kα, IC₅₀: 92 nM		PI3Kγ, IC₅₀: 60 nM									99.82%
Vps34-IN-1								Vps34, IC₅₀: 25 nM				99.79%
GSK2636771		PI3Kβ, Ki: 0.89 nM PI3Kβ, IC₅₀: 5.2 nM										99.83%
Quercetin dihydrate		PI3Kβ, IC₅₀: 5.4 μM	PI3Kγ, IC₅₀: 2.4 μM	PI3Kδ, IC₅₀: 3.0 μM
Autophinib								Vps34, IC₅₀: 19 nM				99.95%
PI3K/AKT-IN-1			PI3Kγ, IC₅₀: 6.99 μM	PI3Kδ, IC₅₀: 4.01 μM								99.62%
Umbralisib	PI3Kα, Kd: >10000 nM	PI3Kβ, Kd: >10000 nM	PI3Kγ, Kd: 1400 nM	PI3Kδ, EC₅₀: 22.2 nM PI3Kδ, Kd: 6.2 nM								98.55%
ZSTK474	PI3Kα, IC₅₀: 16 nM	PI3Kβ, IC₅₀: 44 nM	PI3Kγ, IC₅₀: 49 nM	PI3Kδ, IC₅₀: 4.6 nM								99.88%
AZD 6482	PI3Kα, IC₅₀: 136 nM	PI3Kβ, IC₅₀: 0.69 nM	PI3Kγ, IC₅₀: 47.8 nM	PI3Kδ, IC₅₀: 13.6 nM		PI3K-C2β, IC₅₀: 54.1 nM		hVps34, IC₅₀: 3390 nM				99.93%
Esculetin									PI3K			99.78%
Thymoquinone									PI3K			99.59%
Samotolisib	PI3Kα, IC₅₀: 6.07 nM	PI3Kβ, IC₅₀: 77.6 nM	PI3Kγ, IC₅₀: 23.8 nM	PI3Kδ, IC₅₀: 38 nM								99.27%
PIK-90	p110α, IC₅₀: 11 nM	p110β, IC₅₀: 350 nM	p110γ, IC₅₀: 18 nM	p110δ, IC₅₀: 58 nM	PI3KC2α, IC₅₀: 47 nM	PI3KC2β, IC₅₀: 64 nM		hsVPS34, IC₅₀: 830 nM				99.70%
PF-04691502	PI3Kα, Ki: 1.8 nM	PI3Kβ, Ki: 2.1 nM	PI3Kγ, Ki: 1.9 nM	PI3Kδ, Ki: 1.6 nM								99.91%
AZD8186	PI3Kα, IC₅₀: 35 nM	PI3Kβ, IC₅₀: 4 nM	PI3Kγ, IC₅₀: 675 nM	PI3Kδ, IC₅₀: 12 nM								99.97%
Dihydrocapsaicin									PI3K			99.86%
TGX-221		p110β, IC₅₀: 8.5 nM		p110δ, IC₅₀: 211 nM								99.74%
PIK-93	p110α, IC₅₀: 39 nM	p110β, IC₅₀: 590 nM	p110γ, IC₅₀: 16 nM	p110δ, IC₅₀: 120 nM	PI3KC2α, IC₅₀: 16 μM	PI3KC2β, IC₅₀: 140 nM		hsVPS34, IC₅₀: 320 nM				99.81%
hSMG-1 inhibitor 11e	PI3Kα, IC₅₀: 61 nM		PI3Kγ, IC₅₀: 92 nM									99.81%
GO-203 TFA									PI3K			99.28%
Vps34-PIK-III	PI(3)Kα, IC₅₀: 3.96 μM		PI(3)Kγ, IC₅₀: 3.04 μM	PI(3)Kδ, IC₅₀: 1.2 μM				Vps34, IC₅₀: 18 nM				99.63%
Dactolisib Tosylate	p110α, IC₅₀: 4 nM p110α-H1047R, IC₅₀: 4.6 nM p110α-E545K, IC₅₀: 5.7 nM	p110β, IC₅₀: 75 nM	p110γ, IC₅₀: 5 nM	p110δ, IC₅₀: 7 nM								99.87%
CNX-1351	PI3Kα, IC₅₀: 6.8 nM	PI3Kβ, IC₅₀: 166 nM	PI3Kγ, IC₅₀: 3020 nM	PI3Kδ, IC₅₀: 240.3 nM								99.88%
AS-252424	PI3Kα, IC₅₀: 935 nM	PI3Kβ, IC₅₀: 20 μM	PI3Kγ, IC₅₀: 30 nM	PI3Kδ, IC₅₀: 20 μM								99.71%
Apitolisib	PI3Kα, IC₅₀: 5 nM	PI3Kβ, IC₅₀: 27 nM	PI3Kγ, IC₅₀: 14 nM	PI3Kδ, IC₅₀: 7 nM								99.29%
TG100-115			PI3Kγ, IC₅₀: 83 nM	PI3Kδ, IC₅₀: 235 nM								99.01%
PIK-75 hydrochloride	p110α, IC₅₀: 5.8 nM	p110β, IC₅₀: 1.3 μM	p110γ, IC₅₀: 76 nM	p110δ, IC₅₀: 510 nM	PI3KC2α, IC₅₀: 10 μM	PI3KC2β, IC₅₀: 1 μM		hsVPS34, IC₅₀: 2.6 μM				99.72%
Voxtalisib	p110α, IC₅₀: 39 nM	p110β, IC₅₀: 113 nM	p110γ, IC₅₀: 9 nM	p110δ, IC₅₀: 43 nM								98.81%
Paxalisib	PI3Kα, Ki: 2 nM	PI3Kβ, Ki: 46 nM	PI3Kγ, Ki: 10 nM	PI3Kδ, Ki: 3 nM								99.63%
Linperlisib				PI3Kδ, IC₅₀: 6.4 nM								99.51%
Leniolisib	PI3Kα, IC₅₀: 280 nM	PI3Kβ, IC₅₀: 480 nM	PI3Kγ, IC₅₀: 2.57 μM	PI3Kδ, IC₅₀: 11 nM								99.28%
IC-87114		PI3Kβ, IC₅₀: 75 μM	PI3Kγ, IC₅₀: 29 μM	PI3Kδ, IC₅₀: 0.5 μM								99.83%
1,3-Dicaffeoylquinic acid									PI3K			99.09%
Sophocarpine									PI3K			98.63%
GSK1059615	PI3Kα, IC₅₀: 0.4 nM	PI3Kβ, IC₅₀: 0.6 nM	PI3Kγ, IC₅₀: 2 nM	PI3Kδ, IC₅₀: 5 nM								≥99.0%
AS-605240	PI3Kα, IC₅₀: 60 nM	PI3Kβ, IC₅₀: 270 nM	PI3Kγ, IC₅₀: 8 nM PI3Kγ, Ki: 7.8 nM	PI3Kδ, IC₅₀: 300 nM								98.51%
PI3K-IN-1									PI3K			99.93%
Parsaclisib				PI3Kδ, IC₅₀: 1 nM								99.31%
PI3K-IN-30	PI3Kα, IC₅₀: 5.1 nM	PI3Kβ, IC₅₀: 136 nM	PI3Kγ, IC₅₀: 30.7 nM	PI3Kδ, IC₅₀: 8.9 nM								98.21%
BGT226	PI3Kα, IC₅₀: 4 nM	PI3Kβ, IC₅₀: 63 nM	PI3Kγ, IC₅₀: 38 nM									99.51%
Serabelisib	p110α, IC₅₀: 15 nM	p110β, IC₅₀: 4500 nM	p110γ, IC₅₀: 1900 nM	p110δ, IC₅₀: 13900 nM								99.44%
Flupentixol dihydrochloride	PI3Kα, IC₅₀: 127 nM											99.73%
Bimiralisib	PI3Kα, IC₅₀: 33 nM PI3Kα-H1047R, IC₅₀: 36 nM PI3Kα-E545K, IC₅₀: 136 nM PI3Kα-E542K, IC₅₀: 63 nM	PI3Kβ, IC₅₀: 661 nM	PI3Kγ, IC₅₀: 708 nM	PI3Kδ, IC₅₀: 451 nM				Vps34, IC₅₀: 6486 nM				99.80%
KU-0060648	PI3Kα, IC₅₀: 4 nM	PI3Kβ, IC₅₀: 0.5 nM	PI3Kγ, IC₅₀: 0.594 μM	PI3Kδ, IC₅₀: 0.1 nM								99.62%
PKI-402	PI3Kα, IC₅₀: 2 nM PI3Kα-H1047R, IC₅₀: 3 nM PI3Kα-E545K, IC₅₀: 3 nM	PI3Kβ, IC₅₀: 7 nM	PI3Kγ, IC₅₀: 16 nM	PI3Kδ, IC₅₀: 14 nM								98.43%
A66	p110α, IC₅₀: 32 nM p110α E545K, IC₅₀: 30 nM p110α H1047R, IC₅₀: 43 nM		p110γ, IC₅₀: 3480 nM			PI3K-C2β, IC₅₀: 462 nM						99.73%
Pilaralisib	PI3Kα, IC₅₀: 39 nM	PI3Kβ, IC₅₀: 383 nM	PI3Kγ, IC₅₀: 23 nM	PI3Kδ, IC₅₀: 36 nM				Vps34, IC₅₀: 6974 nM				99.69%
Nemiralisib	PI3Kα, pIC₅₀: 5.3	PI3Kβ, pIC₅₀: 5.8	PI3Kγ, pIC₅₀: 5.2	PI3Kδ, pKi: 9.9								99.80%
VS-5584	PI3Kα, IC₅₀: 16 nM	PI3Kβ, IC₅₀: 68 nM	PI3Kγ, IC₅₀: 25 nM	PI3Kδ, IC₅₀: 42 nM				Vps34, IC₅₀: 7470 nM				99.14%
BGT226 maleate	PI3Kα, IC₅₀: 4 nM	PI3Kβ, IC₅₀: 63 nM	PI3Kγ, IC₅₀: 38 nM									99.87%
GNE-317									PI3K			99.14%
SAR-260301	PI3Kα, IC₅₀: 1539 nM	PI3Kβ, IC₅₀: 23 nM	PI3Kγ, IC₅₀: 10000 nM	PI3Kδ, IC₅₀: 468 nM			PI3KC2γ, IC₅₀: 3812 nM	Vps34, IC₅₀: 183 nM				99.95%
Deoxyshikonin									PI3K			99.96%
PI-103 Hydrochloride	p110α, IC₅₀: 2 nM	p110β, IC₅₀: 3 nM	p110γ, IC₅₀: 15 nM	p110δ, IC₅₀: 3 nM								98.00%
Buparlisib Hydrochloride	p110α, IC₅₀: 52 nM p110α-H1047R, IC₅₀: 58 nM p110α-E545K, IC₅₀: 99 nM	p110β, IC₅₀: 166 nM	p110γ, IC₅₀: 262 nM	p110δ, IC₅₀: 116 nM				Vps34, IC₅₀: 2.4 μM				99.88%
Tenalisib			PI3Kγ, IC₅₀: 33 nM	PI3Kδ, IC₅₀: 25 nM								98.83%
PQR530	PI3Kα, Kd: 0.84 nM	PI3Kβ, Kd: 6.1 nM	PI3Kγ, Kd: 10 nM	PI3Kδ, Kd: 11 nM		PI3KC2β, Kd: 100 nM						99.98%
Zandelisib				PI3Kδ, IC₅₀: 3.5 nM								99.90%
Sonolisib	p110α, IC₅₀: 0.1 nM			p110δ, IC₅₀: 2.9 nM							p120γ, IC₅₀: 1 nM	99.00%
4-Methylbenzylidene camphor									PI3K			99.87%
PI4KIIIbeta-IN-9	PI3Kα, IC₅₀: 2 μM		PI3Kγ, IC₅₀: 1046 nM	PI3Kδ, IC₅₀: 152 nM			PI3KC2γ, IC₅₀: 1 μM					99.01%
Pictilisib dimethanesulfonate	p110α, IC₅₀: 3 nM p110α-H1047R, IC₅₀: 3 nM p110α-E545K, IC₅₀: 3 nM	p110β, IC₅₀: 33 nM	p110γ, IC₅₀: 75 nM	p110δ, IC₅₀: 3 nM								99.72%
PI3Kγ inhibitor AZ2	PI3Kα, pIC₅₀: 5.1	PI3Kβ, pIC₅₀: 4.5	PI3Kγ, pIC₅₀: 9.3	PI3Kδ, pIC₅₀: 6.6								99.25%
AZD3458	PI3Kα, pIC₅₀: 5.1	PI3Kβ, pIC₅₀: 4.5	PI3Kγ, pIC₅₀: 9.1	PI3Kδ, pIC₅₀: 6.5	PI3KC2α, pIC₅₀: 5	PI3KC2β, pIC₅₀: 7.5	PI3KC2γ, pIC₅₀: 5.5			PI3KC3, pIC₅₀: 5.1		99.82%
BAY1082439	PI3Kα	PI3Kβ		PI3Kδ								98.02%
Acalisib	p110α, IC₅₀: 5441 nM	p110β, IC₅₀: 3377 nM	p110γ, IC₅₀: 1389 nM	p110δ, IC₅₀: 12.7 nM				hVps34, IC₅₀: 12682 nM				99.98%
alpha-Bisabolol									PI3K
CZC24832		PI3Kβ, IC₅₀: 1.1 μM	PI3Kγ, IC₅₀: 27 nM	PI3Kδ, IC₅₀: 8.194 μM								99.35%
Vps34-IN-2								Vps34, IC₅₀: 2 nM				99.81%
Duvelisib (R enantiomer)									PI3K
Roginolisib	PI3Kα, IC₅₀: 18500 nM	PI3Kβ, IC₅₀: 2850 nM		PI3Kδ, IC₅₀: 145 nM								99.89%
SF2523	PI3Kα, IC₅₀: 34 nM		PI3Kγ, IC₅₀: 158 nM									98.25%
PI3Kα-IN-9	PI3Kα, IC₅₀: 4.4 nM	PI3Kβ, IC₅₀: 153 nM	PI3Kγ, IC₅₀: 128 nM	PI3Kδ, IC₅₀: 146 nM								99.17%
Brevianamide F	PI3Kα, IC₅₀: 4.8 μM											99.03%
HS-173	PI3Kα, IC₅₀: 0.8 nM											99.04%
PF-06843195	PI3Kα, IC₅₀: 18 nM (in Rat1 fibroblasts) PI3Kα, Ki: 0.018 nM	PI3Kβ, IC₅₀: 360 nM (in Rat1 fibroblasts)		PI3Kδ, IC₅₀: 160 nM (in Rat1 fibroblasts) PI3Kδ, Ki: 0.28 nM								98.01%
AS-604850	PI3Kα, IC₅₀: 4.5 μM		PI3Kγ, IC₅₀: 0.25 μM PI3Kγ, Ki: 0.18 μM									99.95%
Glaucocalyxin A									PI3K			99.39%
AMG 511	PI3Kα, Ki: 4 nM	PI3Kβ, Ki: 6 nM	PI3Kγ, Ki: 1 nM	PI3Kδ, Ki: 2 nM								99.38%
Sophocarpine monohydrate									PI3K			99.91%
AMG319	PI3Kα, IC₅₀: 33 μM	PI3Kβ, IC₅₀: 2.7 μM	PI3Kγ, IC₅₀: 850 nM	PI3Kδ, IC₅₀: 18 nM								99.08%
GDC-0326	PI3Kα, Ki: 0.2 nM	PI3Kβ, Ki: 26.6 nM	PI3Kγ, Ki: 10.2 nM	PI3Kδ, Ki: 4 nM								99.92%
Leniolisib phosphate	PI3Kα, IC₅₀: 280 nM	PI3Kβ, IC₅₀: 480 nM	PI3Kγ, IC₅₀: 2.57 nM	PI3Kδ, IC₅₀: 11 nM								99.10%
YH-306									PI3K			98.01%
PI-3065	p110α, IC₅₀: 910 nM	p110β, IC₅₀: 600 nM		p110δ, IC₅₀: 5 nM								98.97%
MTX-211									PI3K
AZD8154			PI3Kγ									99.69%
GSK-F1									PI3KA, pIC₅₀: 5.8 PI3KB, pIC₅₀: 5.9 PI3KG, pIC₅₀: 5.9 PI3KD, pIC₅₀: 6.4
PI3K-IN-31	PI3Kα, IC₅₀: 3.7 nM	PI3Kβ, IC₅₀: 74 nM	PI3Kγ, IC₅₀: 14.6 nM	PI3Kδ, IC₅₀: 9.9 nM								99.55%
AZD-8835	PI3Kα, IC₅₀: 6.2 nM PI3Kα-E545K, IC₅₀: 6 nM PI3Kα-H1047R, IC₅₀: 5.8 nM	PI3Kβ, IC₅₀: 431 nM	PI3Kγ, IC₅₀: 90 nM	PI3Kδ, IC₅₀: 5.7 nM								98.62%
CAY10505			PI3Kγ, IC₅₀: 30 nM (Neurons)									99.75%
IITZ-01			PI3Kγ, IC₅₀: 2.62 μM									98.18%
PF-04979064	PI3Kα, Ki: 0.13 nM		PI3Kγ, Ki: 0.111 nM	PI3Kδ, Ki: 0.122 nM								99.54%
PKI-179	PI3Kα, IC₅₀: 8 nM	PI3Kβ, IC₅₀: 24 nM	PI3Kγ, IC₅₀: 74 nM	PI3Kδ, IC₅₀: 77 nM								≥98.0%
ETP-45658	PI3Kα, IC₅₀: 22.0 nM	PI3Kβ, IC₅₀: 129.0 nM	PI3Kγ, IC₅₀: 717.3 nM	PI3Kδ, IC₅₀: 39.8 nM								98.97%
Arnicolide D									PI3K			99.20%
CGS 15943			p110γ, IC₅₀: 1.1 μM	p110δ, IC₅₀: 8.47 μM								99.96%
Hederacolchiside A1									PI3K			99.69%
Polygalasaponin F									PI3K			99.85%
GNE-477	PI3Kα, IC₅₀: 4 nM											98.75%
NSC781406	PI3Kα, IC₅₀: 2 nM	PI3Kβ, IC₅₀: 9.4 nM	PI3Kγ, IC₅₀: 2.7 nM	PI3Kδ, IC₅₀: 14 nM								99.97%
PI3K/mTOR Inhibitor-2	PI3Kα, IC₅₀: 3.4 nM	PI3Kβ, IC₅₀: 34 nM	PI3Kγ, IC₅₀: 1 nM	PI3Kδ, IC₅₀: 16 nM								99.10%
Seletalisib				PI3Kδ, IC₅₀: 12 nM								98.88%
SRX3207	PI3Kα, IC₅₀: 861 nM		PI3Kγ, IC₅₀: 11100 nM	PI3Kδ, IC₅₀: 1280 nM								98.50%
PI3K/mTOR Inhibitor-4	PI3Kα, IC₅₀: 0.63 nM	PI3Kβ, IC₅₀: 94.54 nM	PI3Kγ, IC₅₀: 22 nM	PI3Kδ, IC₅₀: 9.2 nM
AQX-016A									PI3K			98.00%
Izorlisib	PI3Kα, IC₅₀: 14 nM PI3Kα-H1047R, IC₅₀: 5.6 nM PI3Kα-E545K, IC₅₀: 6.7 nM PI3Kα-E542K, IC₅₀: 6.7 nM	PI3Kβ, IC₅₀: 120 nM	PI3Kγ, IC₅₀: 36 nM	PI3Kδ, IC₅₀: 500 nM		PI3KC2β, IC₅₀: 5.3 μM						98.93%
PI-828	p110α, IC₅₀: 173 nM											99.09%
NVP-BAG956	PI3Kα, IC₅₀: 56 nM	PI3Kβ, IC₅₀: 446 nM	PI3Kγ, IC₅₀: 117 nM	PI3Kδ, IC₅₀: 35 nM								99.21%
GNE-493	PI3Kα, IC₅₀: 3.4 nM	PI3Kβ, IC₅₀: 12 nM	PI3Kγ, IC₅₀: 16 nM	PI3Kδ, IC₅₀: 16 nM
Umbralisib hydrochloride	PI3Kα, Kd: >10000 nM	PI3Kβ, Kd: >10000 nM	PI3Kγ, Kd: 1400 nM	PI3Kδ, EC₅₀: 22.2 nM PI3Kδ, Kd: 6.2 nM								99.04%
BEBT-908	PI3Kα, IC₅₀: 0.1 μM											99.60%
WYE-687	PI3K alpha, IC₅₀: 81 nM		PI3K gamma, IC₅₀: 3.11 μM									98.05%
PI4K-IN-1	PI3Kα, pIC₅₀: 4.0	PI3Kβ, pIC₅₀: <3.7	PI3Kγ, pIC₅₀: 5.0	PI3Kδ, pIC₅₀: <4.1								98.61%
PIK-294	p110α, IC₅₀: 10 μM	p110β, IC₅₀: 490 nM	p110γ, IC₅₀: 160 nM	p110δ, IC₅₀: 10 nM								99.90%
Vulolisib	PI3Kα, IC₅₀: 0.2 nM	PI3Kβ, IC₅₀: 168 nM	PI3Kγ, IC₅₀: 90 nM	PI3Kδ, IC₅₀: 49 nM								99.60%
(S)-PI3Kα-IN-4	PI3Kα, IC₅₀: 2.3 nM											99.77%
TG 100713	PI3Kα, IC₅₀: 165 nM	PI3Kβ, IC₅₀: 215 nM	PI3Kγ, IC₅₀: 50 nM	PI3Kδ, IC₅₀: 24 nM								99.49%
PIK-75	p110α, IC₅₀: 5.8 nM	p110β, IC₅₀: 1.3 μM	p110γ, IC₅₀: 76 nM	p110δ, IC₅₀: 510 nM	PI3KC2α, IC₅₀: 10 μM	PI3KC2β, IC₅₀: 1 μM		hsVPS34, IC₅₀: 2.6 μM				99.94%
Parsaclisib hydrochloride				PI3Kδ, IC₅₀: 1 nM								98.74%
PI3K/mTOR Inhibitor-11	PI3Kα, IC₅₀: 3.5 nM			PI3Kδ, IC₅₀: 4.6 nM								98.74%
CHMFL-PI3KD-317	PI3Kα, IC₅₀: 62.6 nM	PI3Kβ, IC₅₀: 284 nM	PI3Kγ, IC₅₀: 202.7 nM	PI3Kδ, IC₅₀: 6 nM		PIK3C2B, IC₅₀: 882.3 nM		Vps34, IC₅₀: 1801.7 nM				98.04%
IPI-3063	p110α, IC₅₀: 1170 nM	p110β, IC₅₀: 1508 nM	p110γ, IC₅₀: 2187 nM	p110δ, IC₅₀: 2.5 nM								99.22%
KTC1101	PI3Kα, IC₅₀: 3.72 nM	PI3Kβ, IC₅₀: 36.29 nM	PI3Kγ, IC₅₀: 17.09 nM	PI3Kδ, IC₅₀: 1.22 nM								98.09%
AS-041164	PI3Kα, IC₅₀: 240 nM	PI3Kβ, IC₅₀: 1.4 μM	PI3Kγ, IC₅₀: 70 nM	PI3Kδ, IC₅₀: 1.7 μM								99.02%
PKI-179 hydrochloride	PI3Kα, IC₅₀: 8 nM	PI3Kβ, IC₅₀: 24 nM	PI3Kγ, IC₅₀: 74 nM	PI3Kδ, IC₅₀: 77 nM								99.66%
GS-9901				PI3Kδ, IC₅₀: 1 nM								99.97%
Roginolisib hemifumarate				PI3Kδ, IC₅₀: 145 nM								99.80%
LX2343									PI3K, IC₅₀: 15.99 μM			99.80%
Pilaralisib analogue	PI3K-alpha											99.74%
FD223	PI3Kα, IC₅₀: 51 nM	PI3Kβ, IC₅₀: 29 nM	PI3Kγ, IC₅₀: 37 nM	PI3Kδ, IC₅₀: 1 nM								98.05%
PARP/PI3K-IN-1	PI3Kα, pIC₅₀: 8.25	PI3Kβ, pIC₅₀: 6.54	PI3Kγ, pIC₅₀: 6.08	PI3Kδ, pIC₅₀: 8.13								99.43%
PI3K-IN-2	PI3Kα, IC₅₀: 13 nM	PI3Kβ, IC₅₀: 7.1 nM	PI3Kγ, IC₅₀: 8.6 nM	PI3Kδ, IC₅₀: 190 nM
PI3Kα-IN-4	PI3Kα, IC₅₀: 1.8 nM											99.76%
NVS-PI3-4			PI3Kγ									99.74%
FD274	PI3Kα, IC₅₀: 0.65 nM	PI3Kβ, IC₅₀: 1.57 nM	PI3Kγ, IC₅₀: 0.42 nM	PI3Kδ, IC₅₀: 0.65 nM
PI3K-IN-18	PI3Kα, IC₅₀: 41 nM											≥99.0%
CHMFL-PI4K-127	PI3Kα, IC₅₀: 191 ± 36 nM	PI3Kβ, IC₅₀: 392 ± 27 nM	PI3Kγ, IC₅₀: 324 ± 19 nM	PI3Kδ, IC₅₀: 104 ± 3 nM				Vps34, IC₅₀: 681 ± 25 nM				99.94%
WYE-687 dihydrochloride	PI3K alpha, IC₅₀: 81 nM		PI3K gamma, IC₅₀: 3.11 μM									≥98.0%
SB02024								Vps34
TASP0415914			PI3Kγ, IC₅₀: 29 nM									99.02%
PF-4989216	PI3Kα, Ki: 0.6 nM											99.38%
PIK-293	PI3Kα, IC₅₀: 100 μM	PI3Kβ, IC₅₀: 10 μM	PI3Kγ, IC₅₀: 25 μM	PI3Kδ, IC₅₀: 0.24 μM								99.41%
PI3K-IN-37	PI3Kα, IC₅₀: 6 nM	PI3Kβ, IC₅₀: 8 nM		PI3Kδ, IC₅₀: 4 nM								≥99.0%
GSK2292767				PI3Kδ, pIC₅₀: 10.1								98.89%
PI3K-IN-22	PI3Kα, IC₅₀: 0.9 nM											99.50%
PI3Kδ-IN-15	p110α, IC₅₀: 152 nM	p110β, IC₅₀: 145 nM	p110γ, IC₅₀: 15.3 nM	p110δ, IC₅₀: 0.5 nM								99.52%
ETP-46321	p110α, Ki: 2.3 nM PI3Kα-H1047R, Ki: 2.33 nM PI3Kα-E545K, Ki: 1.77 nM PI3Kα-E542K, Ki: 1.89 nM	p110β, Ki: 170 nM	p110γ, Ki: 179 nM	p110δ, Ki: 14.2 nM								99.34%
NVP-QAV-572									PI3K, IC₅₀: 10 nM			98.05%
PI3Kα/mTOR-IN-1	PI3Kα, Ki: 12.5 nM PI3Kα, IC₅₀: 7 nM (Cell Assay)											99.30%
ON 146040	PI3Kα, IC₅₀: 14 nM	PI3Kβ, IC₅₀: 3 μM	PI3Kγ, IC₅₀: 1 μM	PI3Kδ, IC₅₀: 20 nM
CAL-130 Hydrochloride	p110α, IC₅₀: 115 nM	p110β, IC₅₀: 56 nM	p110γ, IC₅₀: 6.1 nM	p110δ, IC₅₀: 1.3 nM								98.74%
GNE-490	PI3Kα, IC₅₀: 3.5 nM	PI3Kβ, IC₅₀: 25 nM	PI3Kγ, IC₅₀: 15 nM	PI3Kδ, IC₅₀: 5.2 nM
Umbralisib sulfate	PI3Kα, Kd: >10000	PI3Kβ, Kd: >10000	PI3Kγ, Kd: 1400	PI3Kδ, Kd: 6.2
Nemiralisib hydrochloride	PI3Kα, pIC₅₀: 5.3	PI3Kβ, pIC₅₀: 5.8	PI3Kγ, pIC₅₀: 5.2	PI3Kδ, pKi: 9.9
Umbralisib tosylate	PI3Kα, Kd: >10000 nM	PI3Kβ, Kd: >10000 nM	PI3Kγ, Kd: 1400 nM	PI3Kδ, Kd: 6.2 nM
PI3K/HDAC-IN-1	PI3Kα, IC₅₀: 42 nM	PI3Kβ, IC₅₀: 101 nM	PI3Kγ, IC₅₀: 67 nM	PI3Kδ, IC₅₀: 8.1 nM
PI3K-IN-6	PI3Kα, IC₅₀: 850 nM	PI3Kβ, IC₅₀: 7.8 nM		PI3Kδ, IC₅₀: 5.3 nM
PI3Kδ-IN-8	PI3Kα, IC₅₀: 377.2 nM	PI3Kβ, IC₅₀: 241.6 nM	PI3Kγ, IC₅₀: 17.9 nM	PI3Kδ, IC₅₀: 3.3 nM
CHF-6523				PI3Kδ
IHMT-PI3Kδ-372				PI3Kδ, IC₅₀: 14 nM
LAS191954				PI3Kδ, IC₅₀: 2.6 nM
PI3K-IN-9				PI3Kδ
PI3Kγ inhibitor 4	PI3Kα, IC₅₀: 300 nM		PI3Kγ, IC₅₀: 40 nM
PH14	PI3Kα, IC₅₀: 20.3 nM											99.29%
PI3Kδ-IN-10				PI3Kδ, IC₅₀: 2 nM
ATR-IN-15									PI3K, IC₅₀: 5131 nM
ATM Inhibitor-4									PI3K
PI3Kδ-IN-18				PI3Kδ, IC₅₀: 0.1 nM
PI3Kα-IN-8	PI3Kα, IC₅₀: 0.012 μM	PI3Kβ, IC₅₀: 0.21 μM	PI3Kγ, IC₅₀: 0.18 μM	PI3Kδ, IC₅₀: 0.11 μM
IHMT-PI3K-455	PI3Kα, IC₅₀: 6.717 μM	PI3Kβ, IC₅₀: 42.04 nM	PI3Kγ, IC₅₀: 7.1 nM	PI3Kδ, IC₅₀: 0.57 nM
OMS14			PI3Kγ									99.09%
PI3Kα-IN-14	PI3Kα, IC₅₀: 0.14 nM	PI3Kβ, IC₅₀: 25.89 nM	PI3Kγ, IC₅₀: 2.45 nM	PI3Kδ, IC₅₀: 5.69 nM
PI3Kα-IN-6	PI3Kα
PI3Kα-IN-7	PI3Kα	PI3Kβ
PI3K/mTOR Inhibitor-3									PI3K
PI3K/HDAC-IN-2	PI3Kα, IC₅₀: 226 nM	PI3Kβ, IC₅₀: 279 nM	PI3Kγ, IC₅₀: 467 nM	PI3Kδ, IC₅₀: 29 nM
PI3Kα-IN-11	PI3Kα
PI3Kα-IN-19	p110α
PI3Kα-IN-20	PI3Kα
SU-11752			p110γ, IC₅₀: 1.1 μM
XJTU-L453	PI3Kα
TGX-155		PI3Kβ
PI3Kδ-IN-11				PI3Kδ, IC₅₀: 27.5 nM
PI3K-IN-10									PI3K
PI3K/mTOR Inhibitor-9	PI3Kα, IC₅₀: 6.6 μM	PI3Kβ, IC₅₀: >10 μM	PI3Kγ, IC₅₀: 6.6 μM	PI3Kδ, IC₅₀: 0.8 μM
Umbralisib R-enantiomer				PI3Kδ								99.52%
TYM-3-98				PI3Kδ, IC₅₀: 7.1 nM
MJ04			PI3Kγ, IC₅₀: 3667 nM
PP30			p110γ, IC₅₀: 0.68 μM	p110δ, IC₅₀: 0.99 μM
PI3K-IN-34	PI3Kα, IC₅₀: 8.43 μM	PI3Kβ, IC₅₀: 15.84 μM		PI3Kδ, IC₅₀: 30.62 μM
Topoisomerase I/II inhibitor 3									PI3K
MEK/PI3K-IN-2	PI3Kα, IC₅₀: 107 ± 21 nM	PI3Kβ, IC₅₀: 3880 ± 725 nM	PI3Kγ, IC₅₀: 2567 ± 364 nM	PI3Kδ, IC₅₀: 137 ± 7 nM
IHMT-PI3K-315			PI3Kγ, IC₅₀: 4.0 nM	PI3Kδ, IC₅₀: 9.1 nM
PI3Kα-IN-13	PI3Kα
COX-2/PI3K-IN-2									PI3K, IC₅₀: 2.78 nM
Isorhamnetin (Standard)									PI3-K
PI3K/mTOR Inhibitor-8	PI3Kα, IC₅₀: 0.46 nM
PI3Kα-IN-23	PI3Kα-H1047R
COX-2/PI3K-IN-1									PI3K, IC₅₀: 1.14 nM
PI3Kδ/γ-IN-3			PI3Kγ, IC₅₀: 16 nM	PI3Kδ, IC₅₀: 1 nM
17β-Hydroxywortmannin									PI3K, IC₅₀: 0.5 nM
PI3K-IN-35	PI3Kα, IC₅₀: 13.98 μM	PI3Kβ, IC₅₀: 7.22 μM		PI3Kδ, IC₅₀: 10.94 μM
(R)-IHMT-PI3Kδ-372				PI3Kδ, IC₅₀: 19 nM
PI3K/VEGFR2-IN-1									PI3K, IC₅₀: 2.21 μM
MEK/PI3K-IN-1	PI3Kα, IC₅₀: 130 ± 13 nM	PI3Kβ, IC₅₀: 1537 ± 188 nM	PI3Kγ, IC₅₀: 2745 ± 485 nM	PI3Kδ, IC₅₀: 236 ± 29 nM
PI3Kδ-IN-22	PI3Kα, pKi: 7.3	PI3Kβ, pKi: 7.7	PI3Kγ, pKi: 6.5	PI3Kδ, pKi: 9.3
PI3K/mTOR Inhibitor-14									PI3K, IC₅₀: 171.4 nM
PI3Kα-IN-5	PI3Kα, IC₅₀: 0.7 nM
NVP-CLR457	PI3Kα, IC₅₀: 12 ± 1.5 nM	PI3Kβ, IC₅₀: 8.3 ± 1.0 nM	PI3Kγ, IC₅₀: 230 ± 31 nM	PI3Kδ, IC₅₀: 8.3 ± 2.0 nM
PI3Kδ-IN-12	PI3Kα, pKi: 6.7	PI3Kβ, pKi: 6.4	PI3Kγ, pKi: 6.5	PI3Kδ, pIC₅₀: 5.8 PI3Kδ, pKi: 8.0
PI3Kδ-IN-20				PI3Kδ, IC₅₀: 6.4 nM
PI3K-IN-33	PI3Kα, IC₅₀: 11.73 μM	PI3Kβ, IC₅₀: 6.09 μM		PI3Kδ, IC₅₀: 11.18 μM
ATM Inhibitor-3									PI3K
PI3K/mTOR Inhibitor-12	PI3Kα, IC₅₀: 0.06 nM
CXJ-2									PI3K
PI3K-IN-38	p110α, IC₅₀: 0.541 μM
Flupentixol	PI3Kα, IC₅₀: 127 nM
PP487	p110α, IC₅₀: 0.046 μM	p110β, IC₅₀: 0.24 μM	p110γ, IC₅₀: 0.1 μM	p110δ, IC₅₀: 0.027 μM
PI3Kα-IN-1	PI3Kα, IC₅₀: <0.5 nM
PI3Kδ-IN-21	PI3Kα, IC₅₀: 7034 nM	PI3Kβ, IC₅₀: 1660 nM		PI3Kδ, IC₅₀: 13.6 nM
SN32976	PI3Kα, IC₅₀: 15.1 nM	PI3Kβ, IC₅₀: 461 nM	PI3Kγ, IC₅₀: 110 nM	PI3Kδ, IC₅₀: 134 nM
PI3Kγ inhibitor 7	PI3Kα, IC₅₀: 4768 nM	PI3Kβ, IC₅₀: 878.1 nM	PI3Kγ, IC₅₀: 3.42 nM	PI3Kδ, IC₅₀: 355.2 nM
PI3Kδ/γ-IN-2			PI3Kγ, IC₅₀: 4.3 nM	PI3Kδ, IC₅₀: 1 nM
mTOR inhibitor-10	PI3Kα, IC₅₀: 825 nM
MIPS-9922		PI3Kβ, IC₅₀: 63 nM		PI3Kδ, IC₅₀: 2200 nM
PI3Kα-IN-24	PI3Kα, IC₅₀: 0.025 μM
mTOR inhibitor-13	PI3Kα, IC₅₀: 119 nM
PI3Kγ inhibitor 1	PI3Kα, IC₅₀: 10 μM	PI3Kβ, IC₅₀: 10 μM	PI3Kγ, IC₅₀: 100 nM	PI3Kδ, IC₅₀: 100 nM
mTOR inhibitor-16	PI3Kα, IC₅₀: 82 nM
PI3K-IN-54	p110α, IC₅₀: 0.22 nM	p110β, IC₅₀: 1.4 nM		p110δ, IC₅₀: 0.38 nM
AS2541019				p110δ
(S)-GSK-F1	PI3Kα, pIC₅₀: 5.6	PI3Kβ, pIC₅₀: 5.1		PI3Kδ, pIC₅₀: 5.6
PIK-C98	PI3Kα, IC₅₀: 0.59 μM	PI3Kβ, IC₅₀: 1.64 μM	PI3Kγ, IC₅₀: 0.74 μM	PI3Kδ, IC₅₀: 3.65 μM
CAL-130 Racemate				PI3Kδ
mTOR inhibitor-17	PI3Kα, IC₅₀: 1359 nM
CAL-130	p110α, IC₅₀: 115 nM	p110β, IC₅₀: 56 nM	p110γ, IC₅₀: 6.1 nM	p110δ, IC₅₀: 1.3 nM
AM-0687	PI3Kα, IC₅₀: 17600 nM	PI3Kβ, IC₅₀: 2840 nM	PI3Kγ, IC₅₀: 3530 nM	PI3Kδ, IC₅₀: 2.9 nM
TGX-115		PI3Kβ, IC₅₀: 0.13 μM		PI3Kδ, IC₅₀: 0.63 μM
PI3kδ inhibitor 1				PI3Kδ, IC₅₀: 3.8 nM
PI3K/mTOR Inhibitor-1	PI3Kα, IC₅₀: 20 nM	PI3Kβ, IC₅₀: 376 nM	PI3Kγ, IC₅₀: 204 nM	PI3Kδ, IC₅₀: 46 nM
PI3Kdelta inhibitor 1				PI3Kδ, IC₅₀: 1.3 nM
PI3Kγ inhibitor 2			PI3Kγ, Ki: 4 nM

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