2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. TYM-3-98

TYM-3-98 是 PI3Kδ 的选择性抑制剂，IC50 为 7.1 nM。TYM-3-98 抑制 B 淋巴瘤细胞的增殖。TYM-3-98 通过诱导细胞凋亡 (apoptosis)，抑制 PI3K/AKT/mTOR 信号通路。TYM-3-98 小鼠/大鼠模型中表现出良好的药代动力学特征和抗肿瘤活性，且无明显毒性。

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TYM-3-98 Chemical Structure

TYM-3-98 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

TYM-3-98 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TYM-3-98 is a selective inhibitor for PI3Kδ, with an IC50 of 7.1 nM. TYM-3-98 inhibits proliferationso of B-lymphoma cells. TYM-3-98 inhibits PI3K/AKT/mTOR signaling pathway through induction of apoptosis. TYM-3-98 exhibits good pahrmacokinetic characters and antitumor efficacy in mouse/rat model, without significant toxicity[1].

IC50 & Target

PI3Kδ

7.1 nM (IC50)

分子量

592.04

Formula

C28H23ClFN7O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TYM-3-98 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TYM-3-98PI3KApoptosisPhosphoinositide 3-kinaseNSG mouseSprague Dawley ratNIH-3 T3PC-3RAW264.7BCLSU-DHL-6SU-DHL-4OCI-LY7PfeifferFarageMEC-1DOHH2Inhibitorinhibitorinhibit

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Inquiry Information

产品名称：
TYM-3-98
目录号：
HY-163538
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