1. PI3K/Akt/mTOR Apoptosis
  2. PI3K Apoptosis
  3. XJTU-L453

XJTU-L453 是一种 PI3Kα 抑制剂,IC50 值为 0.4 nM。XJTU-L453 可以抑制乳腺癌细胞系 T47D和 MCF7 的增殖,IC50 值分别为 0.2 μM 和 0.5 μM。XJTU-L453 可以抑制 PI3K 通路,诱导细胞周期停滞和细胞凋亡 (apoptosis)。XJTU-L453 在 MCF7 异种移植小鼠中具有抗肿瘤活性。

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XJTU-L453 Chemical Structure

XJTU-L453 Chemical Structure

CAS No. : 3008290-92-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1].

IC50 & Target

PI3Kα

 

分子量

390.44

Formula

C22H22N4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
XJTU-L453
目录号:
HY-169019
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