2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. PI3K-IN-35

PI3K-IN-35 (Compound 6l) 是一种高选择性的 PI3K 抑制剂，其对 PI3K-α、PI3K-β 和 PI3K-δ 的 IC50 分别为 13.98、7.22 和 10.94 μM。PI3K-IN-35 阻滞细胞周期于 G2/M 期并诱导细胞凋亡。PI3K-IN-35 可用于白血病研究。

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PI3K-IN-35 Chemical Structure

PI3K-IN-35 Chemical Structure

CAS No. : 2458163-99-8

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PI3K-IN-35 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K-IN-35 (Compound 6l) is a highly selective PI3K inhibitor with IC50 values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research[1].

IC50 & Target[1]

PI3Kα

13.98 μM (IC50)

PI3Kβ

7.22 μM (IC50)

PI3Kδ

10.94 μM (IC50)

体外研究
(In Vitro)

PI3K-IN-35 (Compound 6l) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].
PI3K-IN-35 (Compound 6l) induces cell cycle arrest toward the G2-M phase (41.61%) and leads to DNA synthesis and apoptosis[1].
PI3K-IN-35 (Compound 6l) (10 μM, 48 hours) results in apoptotic with 16.98% of cells in the early and latest age[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-35 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Leukemia SR cell lines.
Concentration: 10 μM
Incubation Time: 48 hours
Result: Antiproliferative activity with values of 13.59 μM.
分子量

453.50

Formula

C25H23N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K-IN-35 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-352458163-99-8PI3KApoptosisPhosphoinositide 3-kinaseleukemiaanticanceratiproliferativeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147900
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