2. PI3K/Akt/mTOR
  3. mTOR PI3K
  4. PI3K/mTOR Inhibitor-9

PI3K/mTOR Inhibitor-9 (Compound 1) 是一种有效的 mTOR 和 PI3K 抑制剂，对 mTOR、PI3Kα、PI3Kγ 和 PI3Kδ 的 IC50 分别为 38 nM、6.6 μM、6.6 μM 和 0.8 μM。

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PI3K/mTOR Inhibitor-9 Chemical Structure

PI3K/mTOR Inhibitor-9 Chemical Structure

CAS No. : 1392421-71-4

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PI3K/mTOR Inhibitor-9 相关抗体

Top Publications Citing Use of Products

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively[1].

IC50 & Target

mTOR

16 nM (IC50, Ser240/244 cellular assay)

mTOR

38 nM (IC50, phospho-S6 cellular assay)

PI3Kδ

0.8 μM (IC50)

PI3Kα

6.6 μM (IC50)

PI3Kγ

6.6 μM (IC50)

PI3Kβ

>10 μM (IC50)

体外研究
(In Vitro)

PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ[1].
PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50 = 1.98 μM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs = 0.080 /min)[1].
PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/mTOR Inhibitor-9 相关抗体:
分子量

433.51

Formula

C23H27N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/mTOR Inhibitor-9 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-91392421-71-4mTORPI3KMammalian target of RapamycinPhosphoinositide 3-kinaseCYP2D6CYP3A4good permeabilityPhospho-S6Inhibitorinhibitorinhibit

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产品名称：
PI3K/mTOR Inhibitor-9
目录号：
HY-147285
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