2. PI3K/Akt/mTOR
  3. mTOR PI3K
  4. WYE-687 dihydrochloride

WYE-687 dihydrochloride 是一种 ATP 竞争性的 mTOR 抑制剂，IC50 为 7 nM。WYE-687 dihydrochloride 抑制 mTORC1 和 mTORC2 活化。WYE-687 也抑制 PI3Kα 和 PI3Kγ，IC50 分别为 81 nM 和 3.11 μM。

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WYE-687 dihydrochloride Chemical Structure

WYE-687 dihydrochloride Chemical Structure

CAS No. : 1702364-87-1

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规格 价格 是否有货
2 mg ￥4200
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WYE-687 dihydrochloride 的其他形式现货产品:

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Other Forms of WYE-687 dihydrochloride:

WYE-687 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].

IC50 & Target[1][2]

mTOR

7 nM (IC50)

mTORC1

 

mTORC2

 

PI3K alpha

81 nM (IC50)

PI3K gamma

3.11 μM (IC50)

CK1 gamma1

17.8 μM (IC50)

p38 alpha

28.9 μM (IC50)

分子量

601.53

Formula

C28H34Cl2N8O3
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

COA (269 KB)

产品使用指南 (1538 KB)
参考文献

WYE-687 dihydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WYE-6871702364-87-1WYE687WYE 687mTORPI3KMammalian target of RapamycinPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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产品名称：
WYE-687 dihydrochloride
目录号：
HY-15271A
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