2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis PI3K/Akt/mTOR
  3. TRP Channel Apoptosis PI3K Akt
  4. TRPM7-IN-1

TRPM7-IN-1 (compound SUD) 是一种苯甲酰脲衍生物，一种有效的 TRPM7 抑制剂。TRPM7-IN-1 诱导 MCF-7 和 BGC-823 细胞周期停滞和凋亡，减少细胞迁移。TRPM7-IN-1 降低波形蛋白表达并增加 E-钙粘蛋白表达。TRPM7-IN-1 降低 TRPM7 样电流，并且通过激活 PI3K/Akt 信号通路降低 TRPM7 表达。TRPM7-IN-1 是一种通过抑制 TRPM7 表达和功能来抑制乳腺癌和胃癌转移的潜在药物。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TRPM7-IN-1 Chemical Structure

TRPM7-IN-1 Chemical Structure

CAS No. : 1909225-07-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

TRPM7-IN-1 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1].

IC50 & Target[1]

TRPM7

 

PI3K

 

Akt

 

分子量

419.48

Formula

C23H25N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRPM7-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPM7-IN-11909225-07-5TRP ChannelApoptosisPI3KAktTransient receptor potential channelsPhosphoinositide 3-kinasePKBProtein kinase BBenzoylureacell cycle arrestmigrationMCF-7BGC-823vimentinE-cadherinbreastgastric cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TRPM7-IN-1
目录号：
HY-168608
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z