2. PI3K/Akt/mTOR
  3. PI3K
  4. TGX-155

TGX-155  (Synonyms: AZ12649385)

目录号: HY-105666
产品使用指南

摩尔计算器

TGX-155 (AZ12649385) 是一种选择性的 PI3Kβ 抑制剂。TGX-155 在抗血栓中有潜在应用。

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TGX-155 Chemical Structure

TGX-155 Chemical Structure

CAS No. : 351071-90-4

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规格 是否有货
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Customer Review

TGX-155 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGX-155 (AZ12649385) is a selective inhibitor of PI3Kβ. TGX-155 has potential applications in antithrombotic therapy[1][2][3].

IC50 & Target[1]

PI3Kβ

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
PC-3 IC50
72 nM
Compound: TGX-155
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay
[PMID: 22524426]
Sf9 IC50
> 10000 nM
Compound: TGX-155
Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay
Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay
[PMID: 22524426]
Sf9 IC50
> 10000 nM
Compound: TGX-155
Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay
Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay
[PMID: 22524426]
Sf9 IC50
166 nM
Compound: TGX-155
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay
[PMID: 22524426]
体内研究
(In Vivo)

TGX-155 (1.5 mg/kg 和 2.5 mg/kg；静脉注射；单剂量) 以时间和剂量依赖性方式显著改善了兔颈动脉损伤中的循环血流量减少 (CFRs)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

354.37

Formula

C20H19FN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGX-155 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGX-155351071-90-4AZ12649385TGX155TGX 155AZ 12649385AZ-12649385PI3KPhosphoinositide 3-kinaseRabbitCyclic flow reductionsCFRsInhibitorinhibitorinhibit

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目录号：
HY-105666
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