2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K-IN-22

PI3K-IN-22 是一种 PI3Kα/mTOR 双重激酶抑制剂。PI3K-IN-22 对 PI3Kα 和 mTOR 的 IC50s 值分别为 0.9、0.6 nM。PI3K-IN-22 可用于癌症研究。

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PI3K-IN-22 Chemical Structure

PI3K-IN-22 Chemical Structure

CAS No. : 1202884-94-3

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规格 价格 是否有货 数量
1 mg ￥2203
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Customer Review

PI3K-IN-22 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer[1].

IC50 & Target[1]

PI3Kα

0.9 nM (IC50)

mTOR

0.6 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-361 IC50
< 3 nM
Compound: 46
Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs
Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs
[PMID: 20334367]
PC-3 IC50
13 nM
Compound: 46
Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs
Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs
[PMID: 20334367]
体外研究
(In Vitro)

PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of <3.0 and 13.0 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-22 相关抗体:
体内研究
(In Vivo)

PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies[1].
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA361 tumor xenograft nude mice model[1]
Dosage: 50, 25, 10 mg/kg
Administration: i.v., once daily for 5 days weekly (2 rounds)
Result: Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.
Exhibited tumor growth inhibition in 25 and 10 mg/kg.
分子量

624.66

Formula

C31H35F3N8O3
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 15 mg/mL (24.01 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6009 mL 8.0044 mL 16.0087 mL
5 mM 0.3202 mL 1.6009 mL 3.2017 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.50%

COA (283 KB)

产品使用指南 (1538 KB)
参考文献

PI3K-IN-22 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6009 mL 8.0044 mL 16.0087 mL 40.0218 mL
5 mM 0.3202 mL 1.6009 mL 3.2017 mL 8.0044 mL
10 mM 0.1601 mL 0.8004 mL 1.6009 mL 4.0022 mL
15 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6681 mL
20 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0011 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-221202884-94-3PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinnude micetumorMDA361PC3cellscell growthratInhibitorinhibitorinhibit

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目录号：
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