2. Membrane Transporter/Ion Channel
  3. Sodium Channel Potassium Channel
  4. Nav1.8-IN-7

Nav1.8-IN-7 (Example 116) 是选择性 Nav1.8 抑制剂。Nav1.8-IN-7 显示在浓度为 100 nM 时对 Nav1.8 的抑制率为大于 50%。Nav1.8-IN-7 抑制 hERG，IC50 为 15.6 μM。Nav1.8-IN-7 具有用于疼痛研究潜力。

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Nav1.8-IN-7 Chemical Structure

Nav1.8-IN-7 Chemical Structure

CAS No. : 2761181-58-0

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

Nav1.8-IN-7 相关抗体

Top Publications Citing Use of Products

查看 Sodium Channel 亚型特异性产品:

查看所有亚型
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research[1].

体外研究
(In Vitro)

Nav1.8-IN-9 (Example 116；1 μM) 显示对 Nav1.1、Nav1.3、Nav1.4、Nav1.5、Nav1.6 和 Nav1.7 的抑制率分别为 1.2％、3.7％、<1％、<1％、2.6％、<1％[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nav1.8-IN-7 相关抗体:
体内研究
(In Vivo)

Pharmacokinetic Parameters of Nav1.8-IN-7 in male Sprague-Dawley rats[1].

PO (100 mg/kg)
Cmax (ng/mL) 2566
AUC0-24 (ng/mL∗h) 42454
t1/2 (h) 8.7

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

515.84

Formula

C22H18ClF4N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    5％ DMSO + 95％ saline 对受试化合物进行混悬，并经涡旋 2 min，超声 5min 之后配制成给药体系。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Nav1.8-IN-7 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.8-IN-72761181-58-0Sodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAOrallyNav1.8painInhibitorinhibitorinhibit

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目录号：
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