Sodium Channel Inhibitors

Na_v1.1

Na_v1.2

Na_v1.3

Na_v1.4

Na_v1.5

Na_v1.6

Na_v1.7

Na_v1.8

Sodium Channel Inhibitors, Agonists, Antagonists & Activators

Product Name	Na_v1.1	Na_v1.2	Na_v1.3	Na_v1.4	Na_v1.5	Na_v1.6	Na_v1.7	Na_v1.8	Purity
Veratridine							Na_v1.7, IC₅₀: 18.39 μM		99.96%
A-803467								Na_v1.8, IC₅₀: 8 nM	99.09%
PF 05089771							Nav1.7		99.87%
Flecainide acetate					Na_v1.5				98.98%
ICA-121431	hNa_v1.1, IC₅₀: 13 nM		hNa_v1.3, IC₅₀: 23 nM	hNa_v1.4, IC₅₀: 240 nM	hNa_v1.5, IC₅₀: >10 μM	hNa_v1.6, IC₅₀: >10 μM		hNa_v1.8, IC₅₀: >10 μM	98.65%
VX-150								Na_v1.8	98.36%
GDC-0276							Nav1.7		99.95%
PF-06305591								Na_v1.8, IC₅₀: 15 nM	99.92%
Raxatrigine hydrochloride							Nav1.7		98.94%
DS-1971a							hNa_v1.7, IC₅₀: 22.8 nM mNa_v1.7, IC₅₀: 59.4 nM		99.61%
DSP-2230							Nav1.7	Nav1.8	98.33%
PF-06456384 trihydrochloride							Na_v1.7, IC₅₀: 0.01 nM		99.77%
LTGO-33								hNa_v1.8	99.35%
Methocarbamol				Na_v1.4					99.80%
GDC-0310	hNa_v1.1, IC₅₀: 202 nM	hNa_v1.2, IC₅₀: 38 nM		hNa_v1.4, IC₅₀: 3.4 nM	hNa_v1.5, IC₅₀: 551 nM	hNa_v1.6, IC₅₀: 198 nM	Na_v1.7, IC₅₀: 0.6 nM		99.80%
A-887826								Na_v1.8, IC₅₀: 1.1 nM	99.76%
PF 04531083								Na_v1.8	98.96%
Funapide							Na_v1.7	Na_v1.8	99.83%
TC-N 1752			hNa_v1.3, IC₅₀: 0.3 μM	hNa_v1.4, IC₅₀: 0.4 μM	hNa_v1.5, IC₅₀: 1.1 μM		hNa_v1.7, IC₅₀: 0.17 μM	hNa_v1.8, IC₅₀: 0.1 μM	99.18%
Nav1.7 inhibitor							Nav1.7		99.99%
XPC-7724						Nav1.6, IC₅₀: 0.078 μM			99.83%
µ-Conotoxin-CnIIIC acetate				Nav1.4, IC₅₀: 1.3 nM					98.37%
GX-201							Na_v1.7, IC₅₀: <3.2 nM		98.89%
PF-06305591 dihydrate								Na_v1.8, IC₅₀: 1.5 nM	99.84%
Cyfluthrin								Nav1.8	99.52%
Huwentoxin-IV TFA		Nav1.2, IC₅₀: 150 nM	Nav1.3, IC₅₀: 338 nM	Nav1.4, IC₅₀: 400 nM			Nav1.7, IC₅₀: 26 nM		98.52%
PF-05198007							Nav1.7		99.77%
ABBV-318							hNa_v1.7, IC₅₀: 2.8 μM	hNa_v1.8, IC₅₀: 3.3 μM	98.97%
GNE-131							Na_v1.7, IC₅₀: 3 nM		98.15%
(R)-Funapide							Na_v1.7	Na_v1.8	98.05%
NaV1.7 inhibitor-1							h Na_v1.7, IC₅₀: 0.6 nM		99.65%
Mambalgin 1 TFA								Nav1.8
3'-Methoxydaidzein			Nav1.3, IC₅₀: 505 nM				Nav1.7, IC₅₀: 181 nM	Nav1.8, IC₅₀: 397 nM	99.58%
Nav1.7-IN-2							Na_v1.7, IC₅₀: 80 nM		99.81%
NaV1.2/1.6 channel blocker-1		hNaV1.2, IC₅₀: 24.4 μM				rNaV1.6, IC₅₀: 9.8 μM			98.89%
AA43279	Nav1.1, IC₅₀: 9.5 μM	Nav1.2, IC₅₀: 22.8 μM			Nav1.5, IC₅₀: 14.4 μM	Nav1.6, IC₅₀: 11.6 μM
Raxatrigine							Nav1.7		99.85%
GNE-616							hNa_v1.7, Ki: 0.79 nM hNa_v1.7, Kd: 0.38 nM
AMG8379							hNa_v1.7, IC₅₀: 8.5 nM mNa_v1.7, IC₅₀: 18.6 nM
Nav1.7-IN-6							Na_v1.7
(Rac)-AMG8379							hNa_v1.7, IC₅₀: 8.5 nM mNa_v1.7, IC₅₀: 18.6 nM
GS-462808					Nav1.5, IC₅₀: 1.33 μM
Ceratotoxin-1	Nav1.1, IC₅₀: 523 nM	Nav1.2, IC₅₀: 3 nM		Nav1.4, IC₅₀: 888 nM	Nav1.5, IC₅₀: 323 nM
Nav1.8-IN-13								Nav1.8, pIC₅₀: 7.9
ST-2560							Na_v1.7, IC₅₀: 39 nM
δ-Buthitoxin-Hj2a	Nav1.1, EC₅₀: 32 nM
Nav1.8-IN-2								Na_v1.8, IC₅₀: 0.4 nM
GX-674							hNa_v1.7, IC₅₀: 0.1 nM
Huwentoxin-IV		Nav1.2, IC₅₀: 150 nM	Nav1.3, IC₅₀: 338 nM	Nav1.4, IC₅₀: 400 nM			Nav1.7, IC₅₀: 26 nM
PF-06456384							Na_v1.7, IC₅₀: 0.01 nM
GTx1-15	Nav1.1						Nav1.7
Methocarbamol-d₅				Nav1.4
Phrixotoxin 3	Nav1.1, IC₅₀: 288 nM	Nav1.2, IC₅₀: 0.6 nM	Nav1.3, IC₅₀: 42 nM	Nav1.4, IC₅₀: 72 nM	Nav1.5, IC₅₀: 610 nM
Zorevunersen	Na_v1.1
ProTx-III							Na_v1.7, IC₅₀: 2.1 nM
AMG8380							hNa_v1.7, IC₅₀: 0.907 μM mNa_v1.7, IC₅₀: 0.387 μM
VGSCs-IN-1				hNa_v1.4			hNa_v1.7
XPC-5462		Nav1.2, IC₅₀: 10.3 nM				Nav1.6, IC₅₀: 10.9 nM
δ-Buthitoxin-Hj1a	Nav1.1, EC₅₀: 17 nM
Nav1.7-IN-13							Na_v1.7
Pterinotoxin-2			Nav1.3				Nav1.7
ProTx II							Nav1.7
Hainantoxin-III		Nav1.2	Nav1.3				Nav1.7
NAV 26							Na_v1.7, IC₅₀: 0.37 μM		99.79%
Phlo1b							Nav1.7
Phlo1a							Nav1.7
Pterinotoxin-1			Nav1.3				Nav1.7	Nav1.8
Nav1.8-IN-11								Nav1.8, IC₅₀: 0.1 nM
Nav1.8-IN-15								Nav1.8

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