2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Nav1.7-IN-13

Nav1.7-IN-13 (compound 3g) 是钠离子通道抑制剂，可显著抑制 Veratridine (HY-N6691) 诱导的神经元活动。Nav1.7-IN-13 以浓度依赖性方式抑制 DRG 神经元的总 Na+ 电流；减缓了 Navs 的激活。Nav1.7-IN-13 显著缓解了神经损伤 (SNI) 大鼠模型的机械性疼痛行为，具有镇痛活性。

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Nav1.7-IN-13 Chemical Structure

Nav1.7-IN-13 Chemical Structure

CAS No. : 2776235-57-3

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Nav1.7-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Sodium Channel 亚型特异性产品:

查看所有亚型
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity[1].

IC50 & Target

Nav1.7

 

体外研究
(In Vitro)

Nav1.7-IN-13 (compound 3g) 可阻断处于过度兴奋状态的开放状态。Nav1.7-IN-13 (50-150 μM; 16 h) 以剂量依赖性抑制大鼠的 DRG 神经元中钠离子通道激活，且在 150 μM 浓度下不会抑制 hERG 通道电流，具有安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nav1.7-IN-13 相关抗体:
分子量

472.33

Formula

C23H22BrNO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nav1.7-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.7-IN-132776235-57-3Sodium ChannelNa channelsNa+ channelsNav1.7nonopioidpainsynthesized compoundsvoltage-gated sodium channelsInhibitorinhibitorinhibit

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目录号：
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