2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. NaV1.2/1.6 channel blocker-1

NaV1.2/1.6 channel blocker-1 

目录号: HY-152166 纯度: 98.89%
COA 产品使用指南

摩尔计算器

NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂，抑制 rNaV1.6 和 hNaV1.2 的 IC50 值分别为 9.8 和 24.4 μM。NaV1.2/1.6 channel blocker-1 可用于全身性癫痫的研究。

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NaV1.2/1.6 channel blocker-1 Chemical Structure

NaV1.2/1.6 channel blocker-1 Chemical Structure

CAS No. : 1199944-04-1

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规格 价格 是否有货 数量
5 mg ￥744
In-stock
10 mg ￥1128
In-stock
25 mg ￥2256
In-stock
50 mg ￥3344
In-stock
100 mg ￥5000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

NaV1.2/1.6 channel blocker-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1].

IC50 & Target[1]

rNaV1.6

9.8 μM (IC50)

hNaV1.2

24.4 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
26.19 μM
Compound: MV1035
Antiinvasive activity against human A549 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
Antiinvasive activity against human A549 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
[PMID: 31937477]
NCI-H460 IC50
10.12 μM
Compound: MV1035
Antimigratory activity against human H460 cells assessed as inhibition of cell migration measured after 24 hrs by scratch wound healing assay
Antimigratory activity against human H460 cells assessed as inhibition of cell migration measured after 24 hrs by scratch wound healing assay
[PMID: 31937477]
NCI-H460 IC50
17.78 μM
Compound: MV1035
Antiinvasive activity against human H460 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
Antiinvasive activity against human H460 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
[PMID: 31937477]
U-87MG ATCC IC50
11.02 μM
Compound: MV1035
Antimigratory activity against human U87MG cells assessed as inhibition of cell migration measured after 6 hrs by scratch wound healing assay
Antimigratory activity against human U87MG cells assessed as inhibition of cell migration measured after 6 hrs by scratch wound healing assay
[PMID: 31937477]
U-87MG ATCC IC50
2.48 μM
Compound: MV1035
Antiinvasive activity against human U87MG cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
Antiinvasive activity against human U87MG cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
[PMID: 31937477]
体外研究
(In Vitro)

NaV1.2/1.6 channel blocker-1 (compound 13) (1-100 μM) 在稳定表达大鼠 NaV1.6 和人 NaV1.2 同种型的 HEK 293 细胞中分别阻断 48.5% 和 34.0% 的 NaV1.6 和 NaV1.2 钠电流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NaV1.2/1.6 channel blocker-1 相关抗体:
分子量

258.34

Formula

C14H14N2OS
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 12.5 mg/mL (48.39 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8709 mL 19.3543 mL 38.7087 mL
5 mM 0.7742 mL 3.8709 mL 7.7417 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

NaV1.2/1.6 channel blocker-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8709 mL 19.3543 mL 38.7087 mL 96.7717 mL
5 mM 0.7742 mL 3.8709 mL 7.7417 mL 19.3543 mL
10 mM 0.3871 mL 1.9354 mL 3.8709 mL 9.6772 mL
15 mM 0.2581 mL 1.2903 mL 2.5806 mL 6.4514 mL
20 mM 0.1935 mL 0.9677 mL 1.9354 mL 4.8386 mL
25 mM 0.1548 mL 0.7742 mL 1.5483 mL 3.8709 mL
30 mM 0.1290 mL 0.6451 mL 1.2903 mL 3.2257 mL
40 mM 0.0968 mL 0.4839 mL 0.9677 mL 2.4193 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NaV1.2/1.6 channel blocker-11199944-04-1Sodium ChannelNa channelsNa+ channelsrNaV1.6hNaV1.2generalized epilepsyInhibitorinhibitorinhibit

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目录号：
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