2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 信号通路化合物库系列
  6. 离子通道化合物库
离子通道化合物库 - Ion Channel Compound Library

Cat. No.: HY-L166

离子通道的本质是膜结合酶，其催化位点是离子传导孔，经特定的环境刺激 (电压、配体浓度、膜张力、温度等) 后打开或关闭。离子通道为离子在生物膜上的被动扩散提供孔隙。由于对离子具有高度选择性，离子通道一般被分类为钠 (Na+)，钾 (K+)，钙 (Ca2+)， 氯化物 (Cl-) 和非特异性阳离子通道。离子通道是细胞信号传导和体内平衡的重要贡献者。除电信号转导外，离子通道还具有许多功能：调节血管平滑肌舒缩，维持细胞正常体积，调节腺体分泌，蛋白激酶的激活等。因此，离子通道的功能障碍可导致许多疾病，其机制研究更是尤为重要。

MCE 收录了 1,189 种离子通道相关化合物，主要靶向 Na+ 通道、K+ 通道、Ca2+ 通道、GABA 受体、iGluR 等，是心血管、神经系统等疾病研究的重要工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 离子通道化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，1,173 个产品以 10 mM 浓度提供，15 个产品以 2 mM 浓度提供，1 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 1,189 small molecules related to ion channel for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as Calcium Channel, Chloride Channel, iGluR, Potassium Channel and more.

•   Structurally diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

产品详情

Product Details

Formulation:

A collection of 1,189 small molecules related to ion channel supplied as pre-dissolved Solutions or Solid
Solution: 1,173 compounds supplied in 10 mM solution, 15 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

iGluR (156)

nAChR (103)

mAChR (12)

ERK (8)

COX (7)

HIV (6)

PPAR (4)

CFTR (3)

VDAC (3)

Akt (2)

AMPK (2)

CaMK (2)

CXCR (2)

HDAC (2)

HSV (2)

IKK (2)

MEK (2)

MMP (2)

mTOR (2)

NKCC (2)

PI3K (2)

PKC (2)

RSV (2)

AIM2 (1)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Ion Channel Compound Library
    目录号：
    HY-L166
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