2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. NAV 26

NAV 26 (compound 26) 是一种选择性电压门控钠通道 Nav1.7 阻滞剂，IC50 为 0.37 μM。NAV 26 可用于疼痛研究。

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NAV 26 Chemical Structure

NAV 26 Chemical Structure

CAS No. : 1198160-14-3

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规格 价格 是否有货 数量
5 mg ￥3210
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10 mg ￥5140
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Customer Review

NAV 26 相关抗体

Top Publications Citing Use of Products

查看 Sodium Channel 亚型特异性产品:

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Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].

IC50 & Target[1]

Nav1.7

0.37 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
> 30 μM
Compound: 26B, enantiomer 2
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
CHO-K1 IC50
> 33 μM
Compound: 26
Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay
Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay
[PMID: 22770500]
CHO-K1 IC50
> 33 μM
Compound: 26A, enantiomer 1
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
CHO-K1 IC50
> 33 μM
Compound: 26
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
CHO-K1 IC50
> 33 μM
Compound: 26B, enantiomer 2
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
CHO-K1 IC50
> 33 μM
Compound: 26B, enantiomer 2
Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay
Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay
[PMID: 22770500]
HEK293 IC50
> 33 μM
Compound: 26B, enantiomer 2
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.37 μM
Compound: 26
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.41 μM
Compound: 26B, enantiomer 2
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
1.6 μM
Compound: 26B, enantiomer 2
Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
2 μM
Compound: 26A, enantiomer 1
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
3.8 μM
Compound: 26B, enantiomer 2
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
分子量

434.41

Formula

C22H21F3N2O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (287.75 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3020 mL 11.5099 mL 23.0197 mL
5 mM 0.4604 mL 2.3020 mL 4.6039 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

NAV 26 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3020 mL 11.5099 mL 23.0197 mL 57.5493 mL
5 mM 0.4604 mL 2.3020 mL 4.6039 mL 11.5099 mL
10 mM 0.2302 mL 1.1510 mL 2.3020 mL 5.7549 mL
15 mM 0.1535 mL 0.7673 mL 1.5346 mL 3.8366 mL
20 mM 0.1151 mL 0.5755 mL 1.1510 mL 2.8775 mL
25 mM 0.0921 mL 0.4604 mL 0.9208 mL 2.3020 mL
30 mM 0.0767 mL 0.3837 mL 0.7673 mL 1.9183 mL
40 mM 0.0575 mL 0.2877 mL 0.5755 mL 1.4387 mL
50 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1510 mL
60 mM 0.0384 mL 0.1918 mL 0.3837 mL 0.9592 mL
80 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7194 mL
100 mM 0.0230 mL 0.1151 mL 0.2302 mL 0.5755 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAV 261198160-14-3NAV26NAV-26Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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产品名称：
NAV 26
目录号：
HY-118048
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