2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. PKI-166 hydrochloride

PKI-166 hydrochloride 是一种高效、选择性的，具有口服生物活性的 EGFR 酪氨酸激酶抑制剂，IC50 值为 0.7 nM。

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PKI-166 hydrochloride Chemical Structure

PKI-166 hydrochloride Chemical Structure

CAS No. : 2230253-82-2

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PKI-166 hydrochloride 的其他形式现货产品:

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Other Forms of PKI-166 hydrochloride:

PKI-166 hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1].

IC50 & Target

IC50: 0.7 nM (EGFR tyrosine kinase)[1]
体外研究
(In Vitro)

PKI-166 hydrochloride (0-0.5 μM; 1 hour; pretreatment) inhibits EGFR autophosphorylation in human pancreatic cancer cells[1].
PKI-166 hydrochloride (0.03 μM; 6 days) enhances the cytotoxicity mediated by gemcitabine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PKI-166 hydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: L3.6pl cells
Concentration: 0.01 μM, 0.05 μM, 0.5 μM
Incubation Time: 1 hour
Result: Inhibited EGFR autophosphorylation in a dose-dependent manner.

Cell Cytotoxicity Assay[1]

Cell Line: L3.6pl cells
Concentration: 0.03 μM
Incubation Time: 6 days
Result: Enhanced the cytotoxicity mediated by gemcitabine.
体内研究
(In Vivo)

PKI-166 hydrochloride (100 mg/kg; p.o.; daily; for 29 days) inhibits of pancreatic cancer growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks)[1]
Dosage: 100 mg/kg
Administration: Oral administration; daily; for 29 days
Result: Significantly decreased median tumor volume.
分子量

366.84

Formula

C20H19ClN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PKI-166 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKI-1662230253-82-2PKI166PKI 166EGFREpidermal growth factor receptorErbB-1HER1tyrosinekinase,EGFR-TKIpancreaticcancerInhibitorinhibitorinhibit

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产品名称：
PKI-166 hydrochloride
目录号：
HY-110328
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