EGFR Inhibitors

EGFR^L858R, IC₅₀: 12 nM (Enzyme assays)
EGFR^L858R/T790M, IC₅₀: 1 nM (Enzyme assays)

HER2

EGFR

Soluble EGFR, Kd: 0.201 nM
EGFR, Kd: 0.147 nM (Fixed A431 cells)

EGFR, IC₅₀: 2 nM (Cell Free Assay)

EGFR, IC₅₀: 0.5 nM
EGFR^L858R, IC₅₀: 0.4 nM
EGFR^L858R/T790M, IC₅₀: 10 nM

HER2, IC₅₀: 14 nM

EGFR, IC₅₀: 10.2 nM (Cell Free Assay)

ErbB2, IC₅₀: 9.8 nM (Cell Free Assay)

EGFR, IC₅₀: 0.6 μM (Cell Assay)

EGFR

HER2

EGFR, IC₅₀: 92 nM

HER2, IC₅₀: 59 nM

HER2

EGFR, IC₅₀: 6 nM

ErbB2, IC₅₀: 45.7 nM

ErbB4, IC₅₀: 73.7 nM

EGFR, IC₅₀: 3 nM

HER2

EGFR^L858R/T790M, IC₅₀: 1 nM
EGFR^L858R, IC₅₀: 12 nM

EGFR

EGFR, IC₅₀: 2 nM

EGFR^T790M

EGFR, IC₅₀: 4 nM

ErbB2, IC₅₀: 3 nM

HER3, IC₅₀: 4 nM

EGFR (WT)
EGFR exon 20 insertion

HER2

EGFR^T790M, IC₅₀: 0.37 nM
EGFR^L858R/T790M, IC₅₀: 0.29 nM
EGFR^{del19 T790M}, IC₅₀: 0.21 nM

EGFR

EGFR, IC₅₀: 13 nM

HER2, IC₅₀: 38 nM

EGFR, IC₅₀: 5 nM

EGFR, IC₅₀: 2.4 nM

HER2, IC₅₀: 15.7 nM

EGFR, IC₅₀: 0.5 nM
EGFR^L858R, IC₅₀: 0.4 nM
EGFR^L858R/T790M, IC₅₀: 10 nM

HER2, IC₅₀: 14 nM

EGFR, IC₅₀: 7.67 μM

EGFR

EGFR, IC₅₀: 29 nM
EGFR^L858R/T790M, IC₅₀: 495 nM

EGFR, IC₅₀: 7.4 nM

ErbB2, IC₅₀: 9 nM

EGFR

EGFR, IC₅₀: 38.5 nM

ErbB3, IC₅₀: 23 nM

EGFR, IC₅₀: 16 μM (in HepG2 cells)

HER2

HER2, IC₅₀: 6 nM

EGFR^{Exon 19 deletion}, IC₅₀: 9.2 nM (Cell Assay)
EGFR^L858R/T790M, IC₅₀: 10 nM (Cell Assay)

EGFR^L858R, IC₅₀: 12 nM
EGFR^L858R/T790M, IC₅₀: 1 nM

EGFR exon 20 insertion, IC₅₀: 20.4 nM
EGFR^L858R/T790M, IC₅₀: 1.1 nM

Her2 Exon20 YVMA, IC₅₀: 7.5 nM

EGFR, Ki: 6 pM
EGFR, IC₅₀: 25 pM

EGFR, IC₅₀: 10.8 nM (Cell Free Assay)

ErbB2, IC₅₀: 9.2 nM (Cell Free Assay)

EGFR, IC₅₀: 1.9 μM
EGFR^L858R, IC₅₀: 0.019 μM
EGFR^T790M, IC₅₀: 0.19 μM
EGFR^L858R/T790M, IC₅₀: 0.002 μM

EGFR, IC₅₀: 0.3 nM
EGFR^L858R, IC₅₀: 0.2 nM
EGFR^{Exon 19 deletion}, IC₅₀: 0.2 nM

EGFR, DC₅₀: 11.7 nM (HCC827(exon 19 del) cells)
EGFR, DC₅₀: 22.3 nM (H3255 (L858R mutantion) cells)

EGFR^L858R/T790M, Ki: 21.5 nM
EGFR^T790M, Ki: 303.3 nM

HER2

EGFR, IC₅₀: 0.3 nM

ErbB2, IC₅₀: 16 nM

EGFR, IC₅₀: 13 nM

HER2, IC₅₀: 38 nM

EGFR^L858R/T790M, IC₅₀: 1 nM
EGFR^L858R, IC₅₀: 1 nM
EGFR^L861Q, IC₅₀: 6 nM
EGFR, IC₅₀: 25 nM

ErbB4, IC₅₀: 7 nM

ErbB2, IC₅₀: 10 nM

EGFR, IC₅₀: 35 μM (Cell Assay)
EGFR, Ki: 11 μM

EGFR, IC₅₀: 5 nM

HER2, IC₅₀: 20 nM

HER4, IC₅₀: 60 nM

EGFR^{del19 T790M C797S}, IC₅₀: 0.2 nM
EGFR^del19, IC₅₀: 1 nM
EGFR^WT, IC₅₀: 190 nM

HER2

EGFR, IC₅₀: 0.7 nM

EGFR, IC₅₀: 1.1-8.0 nM

EGFR, IC₅₀: 5 nM

EGFR L858R, IC₅₀: 0.18 nM
EGFR^T790M, IC₅₀: 0.18 nM
EGFR (WT), IC₅₀: 7.68 nM

HER1, IC₅₀: 7 nM

HER2, IC₅₀: 2 nM

HER4, IC₅₀: 4 nM

EGFR, IC₅₀: 8 μM (Cell Assay)

ErbB2, IC₅₀: 49 nM (Cell Assay)

ErbB3, IC₅₀: 52 nM (Cell Assay)

ErbB4, IC₅₀: 52 nM (Cell Assay)

EGFR, Kd: 0.22 nM

EGFR, IC₅₀: 2 nM

ErbB2, IC₅₀: 6 nM

EGFR^L858R, IC₅₀: 2 nM (Cell Assay)
EGFR^L858R/T790M, IC₅₀: 8 nM (Cell Assay)
EGFR^E746_A750, IC₅₀: 3 nM (Cell Assay)
EGFR^{E746_A750/T790M}, IC₅₀: 2 nM (Cell Assay)

EGFR, IC₅₀: 23 nM

HER2, IC₅₀: 17 nM

EGFR, IC₅₀: 19 μM

ErbB2, IC₅₀: 0.35 μM

EGFR^L858R/T790M, Ki: 31 nM

EGFR L858R, IC₅₀: 0.147 nM
EGFR L858R/T790M, IC₅₀: 0.063 nM
EGFR L858R/T790M/C797S, IC₅₀: 0.083 nM
EGFRLT/L747S, IC₅₀: 0.396 nM

EGFR

EGFR, Kd: 0.2 nM

HER2, Kd: 0.76 nM

HER3

EGFR, IC₅₀: 3 nM

ErbB2, IC₅₀: 3.4 μM

EGFR, IC₅₀: 10.8 nM

ErbB2, IC₅₀: 9.2 nM

EGFR, IC₅₀: 0.5 nM
EGFR^L858R/T790M, IC₅₀: 12 nM

ErbB2, IC₅₀: 3 nM

ErbB4, IC₅₀: 0.8 nM

EGFR

EGFR^L858R, IC₅₀: 2 nM
EGFR^L858R/T790M, IC₅₀: 5 nM
EGFR^E746_A750, IC₅₀: 2 nM
EGFR^{E746_A750/T790M}, IC₅₀: 14 nM
EGFR, IC₅₀: 24 nM

EGFR (WT), IC₅₀: 7.68 nM
EGFR L858R, IC₅₀: 0.18 nM
EGFR^T790M, IC₅₀: 0.18 nM

EGFR, IC₅₀: 7.4 nM

ErbB2, IC₅₀: 9 nM

EGFR, IC₅₀: 4 nM

EGFR^L858R/T790M
EGFR^L858R
EGFR^{Exon 19 deletion}
EGFR^{Exon 19 deletion/T790M}
EGFR, IC₅₀: 230 nM

EGFR^L858R
EGFR^{Exon 19 deletion/T790M}
EGFR^T790M

EGFR, IC₅₀: 1.48 ± 0.0 nM

HER2, IC₅₀: 7.15 nM

HER4, IC₅₀: 2.49 ± 0.1 nM

EGFR

EGFR, IC₅₀: 92 nM

HER2, IC₅₀: 59 nM

EGFR^T790M, IC₅₀: 0.37 nM
EGFR^L858R/T790M, IC₅₀: 0.29 mM
EGFR^{del19 T790M}, IC₅₀: 0.214 nM

EGFR

EGFR, IC₅₀: 0.24 μM

EGFR/HER2

EGFR, IC₅₀: 370 pM

EGFR exon 20 insertion
EGFR (WT)

HER2

EGFR^T790M, IC₅₀: 0.5 nM
EGFR^L858R/T790M, IC₅₀: 0.3 nM
EGFR (WT), IC₅₀: 6 nM
EGFR^{Exon 19 deletion}, IC₅₀: 0.5 nM

HER2, IC₅₀: 5 nM

EGFR, IC₅₀: 19.9 nM

EGFR (L858R/T790M), IC₅₀: 0.26 nM

EGFR (WT), Kd: 1.8 nM
EGFR^L858R, Kd: 3.8 nM

EGFR, IC₅₀: 34 nM

ErbB2, IC₅₀: 33 nM

EGFR

EGFR^LR/TM, IC₅₀: 15.6 nM
EGFR^19del/TM/CS, IC₅₀: 22.6 nM
EGFR^LR/TM/CS, IC₅₀: 124.5 nM

ErbB1, IC₅₀: 0.3 nM
EGFR, IC₅₀: 2.5 nM

ErbB2, IC₅₀: 1.1 nM

ErbB4, IC₅₀: 0.5 nM

EGFR

EGFR, Ki: 6 pM
EGFR, IC₅₀: 25 pM

EGFR, IC₅₀: 230 nM

HER2, IC₅₀: 7 nM

EGFR L858R, IC₅₀: 0.147 nM
EGFR L858R/T790M, IC₅₀: 0.063 nM
EGFR L858R/T790M/C797S, IC₅₀: 0.083 nM
EGFRLT/L747S, IC₅₀: 0.396 nM

EGFR (WT), IC₅₀: 0.611 nM
EGFR^L858R, IC₅₀: 0.563 nM
EGFR^L861Q, IC₅₀: 0.423 nM
EGFR^T790M, IC₅₀: 45.2 nM

HER2, IC₅₀: 253 nM

HER4, IC₅₀: 84 nM

EGFR (WT), IC₅₀: 18 nM
EGFR^L858R, IC₅₀: 0.7 nM
EGFR^L861Q, IC₅₀: 4 nM
EGFR^L858R/T790M, IC₅₀: 0.1 nM
EGFR^d746-750, IC₅₀: 1.4 nM
EGFR^{d746-750/T790M}, IC₅₀: 0.89 nM

EGFR (WT), Ki: 0.18 nM
EGFR^L858R/T790M, Ki: 0.14 nM

EGFR, IC₅₀: 0.7 μM

EGFR, IC₅₀: 240 nM

EGFR, IC₅₀: 0.017 μM

ErbB2, IC₅₀: 0.08 μM

ErbB4, IC₅₀: 1.91 μM

EGFR (WT), Kd: 17 nM
EGFR L858R, Kd: 10 nM

EGFR

EGFR (WT), IC₅₀: 21 nM
EGFR^L858R, IC₅₀: 63 nM
EGFR^L861Q, IC₅₀: 4 nM

HER4, IC₅₀: 7640 nM

Human HER2

EGFR^L858R/T790M, IC₅₀: 0.007 μM

HER2, IC₅₀: 0.016 μM

EGFR, IC₅₀: 13 nM

ErbB2, IC₅₀: 22.5 nM

EGFR, DC₅₀: 36.51 nM

EGFR, IC₅₀: 4 μM

EGFR, IC₅₀: 0.75 nM
EGFR^L858R, IC₅₀: 0.51 nM
EGFR^L858R/T790M, IC₅₀: 2.3 nM
EGFR^T790M, IC₅₀: 0.79 nM

ErbB2, IC₅₀: 19 nM

EGFR, IC₅₀: 3 nM
EGFR, Ki: 0.05 nM
EGFR (L858R/T790M), IC₅₀: 22 nM

EGFR, IC₅₀: 65 nM

HER2, IC₅₀: 13 nM

HER4, IC₅₀: 8.5 nM

EGFR^{L858R/T790M/C797S}, IC₅₀: 18 nM

EGFR^L858R/T790M, Ki: 21.5 nM
EGFR^T790M, Ki: 303.3 nM

EGFR, IC₅₀: 4.9 μM

ErbB2, IC₅₀: 2.1 μM

EGFR, IC₅₀: 5.47 μM
EGFR, Ki: 3.16 μM

EGFR, IC₅₀: 3 μM (Cell Assay)

EGFR^L858R
EGFR^{Exon 19 deletion}
EGFR^T790M

EGFR, IC₅₀: 0.3 μM

EGFR^T790M, IC₅₀: 20 nM

EGFR (WT), IC₅₀: 7.92 nM
EGFR (C797S/T790M/L858R), IC₅₀: 0.218 nM

HER2, Kd: 0.3 nM

EGFR

EGFR, IC₅₀: 10.4 nM
EGFR^L858R, IC₅₀: 1.1 nM
EGFR^L858R/T790M, IC₅₀: 34 nM
EGFR^{L858R/T790M/C797S}, IC₅₀: 7.2 nM

EGFR, IC₅₀: 0.012 μM

EGFR^19del/TM/CS, IC₅₀: 10.1 nM

EGFR^{L858R/T790M/C797S}, DC₅₀: 10.2 nM
EGFR^{L858R/T790M/C797S}, Kd: 240.2 nM
EGFR^{del19 T790M C797S}, DC₅₀: 36.5 nM
EGFR^L858R/T790M, DC₅₀: 88.5 nM
EGFR^del19, DC₅₀: 75.4 nM
EGFR (WT), DC₅₀: >300 nM

EGFR^{del19 T790M C797S}
EGFR^{L858R/T790M/C797S}

EGFR

EGFR

EGFR^L858R/T790M, DC₅₀: 13.2 nM

EGFR

EGFR (WT), IC₅₀: <10 nM
EGFR L858R, IC₅₀: 1.5 nM
EGFR L858R/T790M, IC₅₀: 0.059 nM
EGFR L858R/T790M/C797S, IC₅₀: 0.064 nM

EGFR, IC₅₀: 3.2 nM
EGFR^T790M, IC₅₀: 8.3 nM

HER2, IC₅₀: 14 nM

ErbB1, IC₅₀: 22 nM

ErbB2, IC₅₀: 38 nM

ErbB4, IC₅₀: 21 nM

EGFR, IC₅₀: 0.75 nM
EGFR^L858R, IC₅₀: 0.5 nM
EGFR^T790M, IC₅₀: 0.79 nM
EGFR^L858R/T790M, IC₅₀: 2.3 nM

ErbB2, IC₅₀: 19 nM

EGFR

EGFR

EGFR, IC₅₀: 1.48 ± 0.0 nM

HER2, IC₅₀: 7.15 ± 0.5 nM

HER4, IC₅₀: 2.49 ± 0.1 nM

EGFR^L858R/T790M

HER2

EGFR^L858R/T790M, IC₅₀: 12 nM
EGFR^C797S, IC₅₀: 13 nM

EGFR L858R, IC₅₀: 0.147 nM
EGFR L858R/T790M, IC₅₀: 0.063 nM
EGFR L858R/T790M/C797S, IC₅₀: 0.083 nM
EGFRLT/L747S, IC₅₀: 0.396 nM

EGFR^L858R/T790M, IC₅₀: 48 nM
EGFR^WT, IC₅₀: 15 nM

EGFR (WT), Kd: 7.1 nM
EGFR L858R, Kd: 4.3 nM

EGFR (WT), IC₅₀: 0.611 nM
EGFR^L858R, IC₅₀: 0.563 nM
EGFR^L861Q, IC₅₀: 0.423 nM
EGFR^T790M, IC₅₀: 45.2 nM

HER2, IC₅₀: 253 nM

HER4, IC₅₀: 84 nM

EGFR exon 20 NPH, IC₅₀: 51.2 nM
EGFR exon 20 ASV insertion, IC₅₀: 51.9 nM
EGFR^L858R/T790M, IC₅₀: 1 nM

Her2 exon 20 YVMA insertion, IC₅₀: 21.2 nM

EGFR^L858R/T790M

EGFR (C797S/T790M/L858R), IC₅₀: 0.0002 μM

EGFR (L858R/T790M), IC₅₀: 0.26 nM

EGFR, IC₅₀: 0.96 nM

EGFR^del19, IC₅₀: 1.3 nM
EGFR^L858R, IC₅₀: 1.5 nM
EGFR^T790M, IC₅₀: 977 nM
EGFR^WT, IC₅₀: 4.0 nM

EGFR L858R/T790M/C797S, IC₅₀: 4.3 ± 0.9 nM
EGFR^L858R/T790M, IC₅₀: 6.6 ± 0.8 nM
EGFR^{del19 T790M C797S}, IC₅₀: 25.6 ± 7.5 nM
EGFR^WT, IC₅₀: 816.0 ± 82 nM

HER2, IC₅₀: 51.5 μM

EGFR, IC₅₀: 0.72 nM
EGFR (L858R/T790M), IC₅₀: 8.2 nM

HER2, IC₅₀: 75.1 nM

HER4, IC₅₀: 2.0 nM

EGFR^L858R/T790M

HER2

EGFR^WT, IC₅₀: 86 nM
EGFR^T790M, IC₅₀: 561.73 nM

EGFR, pIC₅₀: 5.0

EGFR^L858R/T790M, Ki: 31 nM

EGFR, IC₅₀: 9.6 nM

HER2, IC₅₀: 18 nM

HER4, IC₅₀: 40.3 nM

EGFR, IC₅₀: 0.5 nM
EGFR^L858R/T790M, IC₅₀: 12 nM

ErbB2, IC₅₀: 3 nM

ErbB4, IC₅₀: 0.8 nM

EGFR^L858R, IC₅₀: 0.4 nM
EGFR^WT, IC₅₀: 0.5 nM
EGFR^L858R/T790M, IC₅₀: 10 nM

HER2, IC₅₀: 14 nM

EGFR exon 20 insertion
EGFR (WT)

HER2

EGFR, IC₅₀: 10.2 nM

ErbB2, IC₅₀: 9.8 nM

EGFR^L858R/T790M, IC₅₀: 15 nM

HER2

EGFR (L858R/T790M), IC₅₀: <1 nM

HER3, IC₅₀: 49 nM

EGFR, IC₅₀: 10.52 nM

EGFR^{L858R/T790M/C797S}
EGFR^{del19 T790M C797S}

EGFR, IC₅₀: 5.02 μM

HER2, IC₅₀: 0.83 μM

EGFR, IC₅₀: 30 nM

HER2

EGFR (WT), IC₅₀: 18 nM
EGFR^L858R, IC₅₀: 0.7 nM
EGFR^L861Q, IC₅₀: 4 nM
EGFR^L858R/T790M, IC₅₀: 0.1 nM
EGFR^d746-750, IC₅₀: 1.4 nM
EGFR^{d746-750/T790M}, IC₅₀: 0.89 nM

EGFR-TK phosphorylation, EC₅₀: 110 nM

HER2, EC₅₀: 244 nM

EGFR^{L858R/T790M/C797S}
EGFR^{del19 T790M C797S}

EGFR, IC₅₀: 4 nM

EGFR^T790M

EGFR (WT), IC₅₀: 4584 nM

HER2(WT), IC₅₀: 49 nM
HER2 YVMA, IC₅₀: 42 nM

HER2

EGFR (WT), IC₅₀: 6.3 μM

HER2, IC₅₀: 18 nM

EGFR, IC₅₀: <10 nM

EGFR (WT), IC₅₀: 37 nM
EGFR^L858R/T790M, IC₅₀: 1.7 nM
EGFR^{L858R/T790M/C797S}, IC₅₀: >300 nM

EGFR, IC₅₀: 2.3 nM

HER2, IC₅₀: 234 nM

EGFR

EGFR^WT, IC₅₀: 0.28 μM
EGFR^T790M, IC₅₀: 5.02 μM

EGFR, IC₅₀: 0.173 ± 0. μM

HER2, IC₅₀: 0.125 ± 0. μM

EGFR^L858R/T790M, IC₅₀: 3.5 nM
EGFR (WT), IC₅₀: 1290 nM
EGFR^T790M, IC₅₀: 6.7 nM
EGFR^L858R, IC₅₀: 2.1 nM

HER2, IC₅₀: 0.03 μM

EGFR, IC₅₀: 0.129 μM

EGFR, pIC₅₀: 10.6

ErbB2, IC₅₀: 45 μM

EGFR^T790M, IC₅₀: 0.08 μM
EGFR^WT, IC₅₀: 0.13 μM

EGFR, IC₅₀: 0.103 μM

EGFR, IC₅₀: 1.623 μM

HER1, IC₅₀: 20 nM

HER2, IC₅₀: 30 nM

EGFR^del19, IC₅₀: 119 nM
EGFR^L858R, IC₅₀: 820 nM
EGFR^WT, IC₅₀: >10 μM
EGFR^L858R/T790M, IC₅₀: >10 μM

EGFR, IC₅₀: 0.493 μM
EGFR^L858R, IC₅₀: 102.60 μM
EGFR^T790M, IC₅₀: 461.63 μM

EGFR^WT, IC₅₀: 0.32 μM

HER2

EGFR, IC₅₀: 5.827 μM

EGFR

EGFR^{L858R/T790M/C797S}, IC₅₀: 0.053 μM

EGFR

EGFR^ex19del, IC₅₀: 136.3 nM
EGFR^19del/TM/CS, IC₅₀: 161.2 nM

EGFR, IC₅₀: 0.083 μM
EGFR^L858R, IC₅₀: 0.053 μM
EGFR^T790M, IC₅₀: 0.026 μM

EGFR, IC₅₀: 560 μM

EGFR, IC₅₀: 0.38 nM
EGFR^{L858R/T790M/C797S}, IC₅₀: 2.2 nM

HER2, IC₅₀: 3.5 nM

HER4, IC₅₀: 1.6 nM

EGFR L858R, IC₅₀: 1.7 nM
EGFR (ex19del), IC₅₀: 2.7 nM
EGFR L858R/T790M, IC₅₀: 0.56 nM
EGFR (ex19del/T790M), IC₅₀: 1.1 nM
EGFR (WT), IC₅₀: 8.2 nM

HER2, IC₅₀: 110 nM

HER4, IC₅₀: 2.6 nM

EGFR, IC₅₀: 0.34 μM

EGFR, IC₅₀: 0.38 nM

EGFR, IC₅₀: 0.6 nM

HER2, IC₅₀: 0.6 nM

EGFR (WT), IC₅₀: 37.21 nM

EGFR L858R/T790M

EGFR^T790M, IC₅₀: 5.3 nM
EGFR, IC₅₀: 8.3 nM

ErbB2, IC₅₀: 8.1 nM

ErbB4, IC₅₀: 3.2 nM

EGFR (L858R/T790M)

EGFR^T790M, IC₅₀: 65.0 nM
EGFR^L858R/T790M, IC₅₀: 13.6 nM

EGFR^L858R/T790M, IC₅₀: 138 nM

Her2 exon 20 YVMA insertion, IC₅₀: <200 nM

EGFR

EGFR, IC₅₀: 3267 nM

EGFR, IC₅₀: 0.6 nM

EGFR, IC₅₀: 272.9 nM

EGFR, IC₅₀: 0.54 μM

EGFR, pIC₅₀: 4.85

HER2, pIC₅₀: 4.74

EGFR^L858R/T790M, IC₅₀: 0.33 μM
EGFR^{L858R/T790M/C797S}, IC₅₀: 0.133 μM

EGFR, IC₅₀: 3 nM

ErbB2

EGFR, IC₅₀: 6.15 nM
HER1, IC₅₀: 9.78 nM

EGFR, IC₅₀: 5.3 nM

EGFR, IC₅₀: 42.3 nM

ErbB2, : 0.68 μM

EGFR^T790M, IC₅₀: 541.7 nM
EGFR^L858R/T790M, IC₅₀: 132.1 nM

HER2

EGFR (WT), IC₅₀: 1.6 nM

Her2 exon 20 YVMA insertion, IC₅₀: <200 nM

EGFR, DC₅₀: 34.8 nM

HER2, IC₅₀: 0.18 mM

EGFR (WT), IC₅₀: 0.40 μM

HER2, IC₅₀: 8 nM

EGFR^del19, IC₅₀: <50 nM
EGFR^L858R, IC₅₀: <50 nM
EGFR^L858R/T790M, IC₅₀: <50 nM
EGFR^{del19 T790M C797S}, IC₅₀: <50 nM
EGFR (C797S/T790M/L858R), IC₅₀: <50 nM
EGFR^{del19 T790M}, IC₅₀: <50 nM

EGFR, IC₅₀: 0.33 μM

EGFR, IC₅₀: 0.4 μM

EGFR, IC₅₀: 38.5 nM

EGFR, IC₅₀: 0.2396 μM

EGFR, IC₅₀: 56.78 ± 4. μM

EGFR, IC₅₀: 48.6 nM

EGFR, IC₅₀: 25.8 nM
EGFR^T790M, IC₅₀: 182.3 nM

EGFR (WT), IC₅₀: 500-1500 n nM

HER2(WT), IC₅₀: <200 nM
HER2 YVMA, IC₅₀: <200 nM

EGFR (WT), IC₅₀: 7 nM
EGFR^L858R/T790M, IC₅₀: 28 nM

EGFR, IC₅₀: 0.203 μM

HER2, IC₅₀: 0.088 μM

EGFR

EGFR (WT), IC₅₀: 1-10 nM
EGFR (L858R/T790M/C797S), IC₅₀: <1 nM

EGFR, IC₅₀: 0.1 μM

EGFR (WT), IC₅₀: 0.1 nM

EGFR^L858R/T790M

EGFR, IC₅₀: 20.17 nM

EGFR^L858R/T790M, IC₅₀: 42 ± 2 nM
EGFR^{L858R/T790M/C797S}, IC₅₀: 137 ± 6 nM
EGFR (WT), IC₅₀: 743 ± 20 nM

EGFR, IC₅₀: 8.264 μM

EGFR, IC₅₀: 0.023 μM

EGFR, IC₅₀: 0.358 μM
EGFR^L858R, IC₅₀: 86.02 μM
EGFR^T790M, IC₅₀: 432.67 μM

Her2 exon 20 YVMA insertion, IC₅₀: <200 nM

EGFR^L858R/T790M, IC₅₀: 3.9 nM
EGFR^WT, IC₅₀: 70 nM

EGFR, IC₅₀: 395.2 nM

EGFR^{L858R/T790M/C797S}, IC₅₀: 0.128 μM

EGFR^L858R, IC₅₀: 21 nM
EGFR^L858R/T790M, IC₅₀: 48 nM

EGFR, IC₅₀: 0.138 μM

HER2, IC₅₀: 0.092 μM

EGFR, IC₅₀: 0.19 μM

EGFR, pIC₅₀: 19.9 nM

HER2, IC₅₀: 121 nM

EGFR, IC₅₀: 0.054 μM

EGFR

HER2

HER2

EGFR^L858R/T790M, IC₅₀: 10 ± 1
EGFR (WT), IC₅₀: 29 ± 2
EGFR^{L858R/T790M/C797S}, IC₅₀: 242 ± 9

EGFR (WT), IC₅₀: 19.09 nM

HER2(WT), IC₅₀: 120.01 nM
HER2 (A775_G776insYVMA), IC₅₀: 2.35 nM

EGFR^{L858R/T790M/C797S}, IC₅₀: 0.54 nM
EGFR (WT), IC₅₀: 4.91 nM

HER2

EGFR, IC₅₀: 4 μM

HER2

EGFR, IC₅₀: 11 μM

HER2, IC₅₀: 16.9 μM

EGFR (WT), IC₅₀: 0.24 nM
EGFR^L858R/T790M, IC₅₀: 7.25 nM
EGFR^L858R, IC₅₀: 0.46 nM
EGFR^T790M, IC₅₀: 1.79 nM

HER2

HER2

ErbB2

HER2

EGFR, IC₅₀: 2 nM