2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-21

EGFR-IN-21 是一种有效的 EGFR 抑制剂，IC50 为 0.38 nM。EGFR-IN-21 具有抗肿瘤活性。

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EGFR-IN-21 Chemical Structure

EGFR-IN-21 Chemical Structure

CAS No. : 2648206-31-7

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EGFR-IN-21 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1].

IC50 & Target[1]

EGFR

0.38 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-21 相关抗体:
体内研究
(In Vivo)

EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse[1].
EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

759.68

Formula

C36H44BrN10O2P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-212648206-31-7EGFREpidermal growth factor receptorErbB-1HER1HEK293TPC9 EGFR-Del19/T790M/C797SInhibitorinhibitorinhibit

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产品名称：
EGFR-IN-21
目录号：
HY-142678
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