2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Thymidylate Synthase
  4. EGFR/HER2/TS-IN-2

EGFR/HER2/TS-IN-2 (compound 17) 是一种有效的 EGFR/HER2 和 TS 抑制剂，其 IC50 分别为 0.173、0.125 和 1.12 μM。EGFR/HER2/TS-IN-2 对 MDA-MB-231 癌细胞具有细胞毒性活性，其 IC50 为 1.69 μM。

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EGFR/HER2/TS-IN-2 Chemical Structure

EGFR/HER2/TS-IN-2 Chemical Structure

CAS No. : 2444364-04-7

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EGFR/HER2/TS-IN-2 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].

IC50 & Target

EGFR

0.173 ± 0. μM (IC50)

HER2

0.125 ± 0. μM (IC50)

体外研究
(In Vitro)

EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR/HER2/TS-IN-2 相关抗体:
分子量

511.62

Formula

C26H21N7OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR/HER2/TS-IN-2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2/TS-IN-22444364-04-7EGFRThymidylate SynthaseEpidermal growth factor receptorErbB-1HER1BenzothiazoleCyano pyrimidineDual EGFR/HER2 inhibitorMultitargetThymidylate synthaseAntitumor activityhuman epidermal growth factor receptor 2Inhibitorinhibitorinhibit

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