2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. Disitamab vedotin

Disitamab vedotin  (Synonyms: 维迪西妥单抗; RC48)

目录号: HY-P9985 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Disitamab vedotin (RC48) 是一种抗体-活性分子偶联物 (ADC)，包含抗人表皮生长因子受体2 (HER2) 的单克隆抗体，该单克隆抗体通过可降解连接子结合到细胞毒性剂 MMAE。Disitamab vedotin 增强抗肿瘤免疫。

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Disitamab vedotin Chemical Structure

Disitamab vedotin Chemical Structure

CAS No. : 2136633-23-1

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规格 价格 是否有货 数量
1 mg ￥3400
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Disitamab vedotin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity[1].

IC50 & Target[1]

HER2

 

体外研究
(In Vitro)

The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Disitamab vedotin 相关抗体:
Clinical Trial
分子量

149000 (average)

CAS 号
性状

固体

颜色

White to light yellow

中文名称

维迪西妥单抗
运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: ≥99.0%

COA (266 KB) SEC-HPLC (178 KB)

产品使用指南 (1538 KB)
参考文献

Disitamab vedotin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disitamab vedotin2136633-23-1RC48维迪西妥单抗RC 48RC-48Antibody-Drug Conjugates (ADCs)EGFRAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1anti-HER2antibodyMMAEantitumorimmunitygastriccancerbreastInhibitorinhibitorinhibit

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