2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Btk EGFR Itk
  4. EGFR-IN-40

EGFR-IN-40 (compound 3z) 是一种有效的 BTK、EGFR 和 ITK 抑制剂，IC50 值分别为 1.2 nM、5.3 nM 和 46.1 nM。

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EGFR-IN-40 Chemical Structure

EGFR-IN-40 Chemical Structure

CAS No. : 1466445-39-5

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EGFR-IN-40 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].

IC50 & Target[1]

EGFR

5.3 nM (IC50)

BTK

1.2 nM (IC50)

ITK

46.1 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCC827 IC50
25.9 nM
Compound: 3z
Antiproliferative activity against gefitinib-sensitive human HCC827 cells harboring EGFR E746 to A750 deletion after 72 hrs by MTS assay
Antiproliferative activity against gefitinib-sensitive human HCC827 cells harboring EGFR E746 to A750 deletion after 72 hrs by MTS assay
[PMID: 24053674]
NCI-H1975 IC50
3518 nM
Compound: 3z
Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells expressing T790M/L858R mutation after 72 hrs by MTS assay
Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells expressing T790M/L858R mutation after 72 hrs by MTS assay
[PMID: 24053674]
分子量

428.44

Formula

C23H20N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-40 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-401466445-39-5BtkEGFRItkBruton tyrosine kinaseEpidermal growth factor receptorErbB-1HER1Interleukin-2 inducible T-cell kinaseIL2 inducible T-cell kinaseInhibitorinhibitorinhibit

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产品名称：
EGFR-IN-40
目录号：
HY-143901
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