2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-75

EGFR-IN-75 是一种 EGFRWT 和 EGFRT790M 抑制剂，IC50 值分别为 0.28 μM 和 5.02 μM。EGFR-IN-75 具有抗癌和抗氧化活性。

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EGFR-IN-75 Chemical Structure

EGFR-IN-75 Chemical Structure

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EGFR-IN-75 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-75 is an EGFRWT and EGFRT790M inhibitor with IC50 values of 0.28 μM and 5.02 μM, respectively. EGFR-IN-75 shows anticancer and antioxidant activity[1].

IC50 & Target[1]

EGFRWT

0.28 μM (IC50)

EGFRT790M

5.02 μM (IC50)

体外研究
(In Vitro)

EGFR-IN-75 (compound 2) shows cytotoxicity against MCF-7 and A549 cell lines with IC50 values of 4.92 μM and 4.69 μM, respectively[1].
EGFR-IN-75 (compound 2) also has the best antioxidant property, decreasing the radical scavenging activity by 78%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-75 相关抗体:
分子量

274.32

Formula

C10H6N6S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-75 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-75EGFREpidermal growth factor receptorErbB-1HER1anticancerantioxidant activityEGFRWTEGFRT790MInhibitorinhibitorinhibit

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产品名称：
EGFR-IN-75
目录号：
HY-152144
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