2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-56

EGFR-IN-56 (Compound 13a) 是一种有效的 EGFR 抑制剂，对EGFRT790M 和 EGFRT790M/L858R 的 IC50 值分别为 541.7 nM 和 132.1 nM。EGFR-IN-56 在 G2/M 期阻滞癌细胞，诱导细胞凋亡 (apoptosis)。

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EGFR-IN-56 Chemical Structure

EGFR-IN-56 Chemical Structure

CAS No. : 2477726-83-1

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EGFR-IN-56 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].

IC50 & Target

EGFRT790M

541.7 nM (IC50)

EGFRL858R/T790M

132.1 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
4.22 μM
Compound: 13a
Antiproliferation activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferation activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32912435]
HeLa IC50
20.91 μM
Compound: 13a
Antiproliferation activity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferation activity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32912435]
L02 IC50
> 50 μM
Compound: 13a
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32912435]
MCF7 IC50
0.66 μM
Compound: 64
Anticancer activity against human MCF7 cells incubated for 48 hrs by MTT assay
Anticancer activity against human MCF7 cells incubated for 48 hrs by MTT assay
[PMID: 33992931]
MCF7 IC50
11.69 μM
Compound: 13a
Antiproliferation activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferation activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32912435]
NCI-H1975 IC50
2.19 μM
Compound: 13a
Antiproliferation activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutation assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferation activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutation assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32912435]
分子量

434.51

Formula

C23H22N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-56 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-562477726-83-1EGFRApoptosisEpidermal growth factor receptorErbB-1HER1A549H1975HelaMCF–7anticanceranti-proliferationInhibitorinhibitorinhibit

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