2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. Cyclic(YCDGFYACYMDV)

Cyclic(YCDGFYACYMDV) 是一种 HER2 信号传导抑制剂，具有抗癌活性。Cyclic(YCDGFYACYMDV) 在水溶液中自组装成纳米颗粒，通过与癌细胞上的 HER2 靶向结合转化为纳米原纤维，来破坏 HER2 二聚化和随后的下游信号事件，从而导致癌细胞凋亡 (Apoptosis)。这种对 HER2 乳腺癌的抑制作用在小鼠异种移植模型中被证明有效。

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Custom Peptide Synthesis

Cyclic(YCDGFYACYMDV) Chemical Structure

Cyclic(YCDGFYACYMDV) Chemical Structure

CAS No. : 535959-77-4

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Cyclic(YCDGFYACYMDV) 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclic(YCDGFYACYMDV) is a HER2 signaling pathway inhibitor with anti-cancer activity. This compound self-assembles into nanoparticles in aqueous solution and transforms into nanofibers upon specific binding to HER2 on cancer cells. This transformation disrupts HER2 dimerization and subsequent downstream signaling events, leading to cancer cell apoptosis (Apoptosis). The inhibitory effects on HER2 positive breast cancer have been demonstrated to be effective in a murine xenograft model[1].

IC50 & Target

HER2

 

分子量

1447.61

Formula

C65H82N12O20S3
CAS 号
Sequence

Tyr-Cys-Asp-Gly-Phe-Tyr-Ala-Cys-Tyr-Met-Asp-Val (Disulfide bridge: Cys2-Cys8)
Sequence Shortening

YCDGFYACYMDV (Disulfide bridge: Cys2-Cys8)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cyclic(YCDGFYACYMDV) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic(YCDGFYACYMDV)535959-77-4EGFRApoptosisEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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