2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Simotinib hydrochloride

Simotinib hydrochloride 是一种选择性、特异性、口服生物利用度高的 EGFR 酪氨酸激酶抑制剂，IC50 为 19.9 nM。抗肿瘤活性.。

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Simotinib hydrochloride Chemical Structure

Simotinib hydrochloride Chemical Structure

CAS No. : 1538617-88-7

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Simotinib hydrochloride 的其他形式现货产品:

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Other Forms of Simotinib hydrochloride:

Simotinib hydrochloride 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].

IC50 & Target

EGFR

19.9 nM (pIC50)

体外研究
(In Vitro)

Simotinib hydrochloride inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Simotinib hydrochloride 相关抗体:
体内研究
(In Vivo)

Simotinib hydrochloride has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

537.41

Formula

C25H27Cl2FN4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Simotinib hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simotinib1538617-88-7EGFREpidermal growth factor receptorErbB-1HER1hydrochlorideselectivespecificorallybioavailableantineoplasticInhibitorinhibitorinhibit

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产品名称：
Simotinib hydrochloride
目录号：
HY-101820A
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