2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-52

EGFR-IN-52 (Compound 4) 是一种有效的 EGFR 抑制剂，对EGFR 、EGFR L858R-TK 和 EGFR T790M-TK 的 IC50 值分别为 0.358、86.02 和 432.67 µM。EGFR-IN-52 对癌细胞具有毒性，诱导细胞凋亡 (apoptosis)。

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EGFR-IN-52 Chemical Structure

EGFR-IN-52 Chemical Structure

CAS No. : 454436-75-0

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EGFR-IN-52 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

IC50 & Target

EGFR

0.358 μM (IC50)

EGFRL858R

86.02 μM (IC50)

EGFRT790M

432.67 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
3.16 μM
Compound: 4
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
[PMID: 32361329]
HepG2 IC50
3.79 μM
Compound: 4
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
[PMID: 32361329]
MCF7 IC50
16.96 μM
Compound: 4
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
[PMID: 32361329]
WI-38 IC50
176 μM
Compound: 4
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
[PMID: 32361329]
分子量

382.44

Formula

C19H18N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-52 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-52454436-75-0EGFRApoptosisEpidermal growth factor receptorErbB-1HER1HCT116HepG2MCF7anticancerBaxBcl2Inhibitorinhibitorinhibit

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