2. PROTAC JAK/STAT Signaling Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway PI3K/Akt/mTOR
  3. PROTACs EGFR ERK Akt
  4. TX2-121-1

TX2-121-1 是一种有效的和选择性的 Her3 (ErbB3) 降解剂，结构中包括疏水性金刚烷。TX2-121-1 对 Her3 的 IC50 为 49 nM。TX2-121-1 可抑制 Her3 依赖性信号传导和 Her3 的异源二聚化。TX2-121-1 具有抗细胞增殖的能力。TX2-121-1 可用于肿瘤的研究。(粉色: Her3 抑制剂 (HY-164988); 黑色: 连接子; 蓝色: Adamantane (HY-N2427))

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TX2-121-1 Chemical Structure

TX2-121-1 Chemical Structure

CAS No. : 1603845-42-6

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TX2-121-1 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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ERK ERK1 ERK2 ERK5 ERK8

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TX2-121-1 is a potent and selective Her3 (ErbB3) degrader that contains a hydrophobic adamantane moiety. TX2-121-1 has an IC50 of 49 nM for Her3. TX2-121-1 inhibits Her3-dependent signaling and heterodimerization of Her3. TX2-121-1 has the ability to inhibit cell proliferation. TX2-121-1 can be used in the study of tumors. (Pink: Her3 inhibitor (HY-164988); Black: Linker; Blue: Adamantane (HY-N2427))[1].

IC50 & Target[1]

HER3

49 nM (IC50)

体外研究
(In Vitro)

TX2-121-1 (1-5 μM；12 小时) 在 PC9 GR4 细胞中可诱导 Her3 降解，抑制下游 Erk 和 Akt 的磷酸化及细胞增殖[1]。
TX2-121-1 (1 μM；6 小时) 在 PC9 GR4 细胞中能干扰 Her3 与 Her2、c-Met 异源二聚化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TX2-121-1 相关抗体:

Western Blot Analysis[1]

Cell Line: PC9 GR4 cells
Concentration: 1 and 5 μM
Incubation Time: 12 h
Result: Significantly inhibited the level of Her3.
Inhibited the phosphorylation levels of Erk and Akt.
分子量

716.91

Formula

C42H52N8O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TX2-121-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX2-121-11603845-42-6PROTACsEGFRERKAktEpidermal growth factor receptorErbB-1HER1Extracellular signal regulated kinasesPKBProtein kinase BPC9 GR4 cellsInhibitorinhibitorinhibit

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产品名称：
TX2-121-1
目录号：
HY-118998
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