2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-125

EGFR-IN-125 (example 37) 是一种有效的 EGFR 抑制剂，对 EGFR (d746-750/T790M/C779S)、EGFR (L858R/T790M/C797S)、EGFR (d746-750/C797S)、EGFR (L858R/C797S) 和 EGFR (野生型) 的 IC50 值分别为 <0.3 nM、0.52 nM、0.5 nM、0.69 nM 和 0.92 nM。

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EGFR-IN-125 Chemical Structure

EGFR-IN-125 Chemical Structure

CAS No. : 2472802-77-8

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EGFR-IN-125 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S), and EGFR (wild-type), respectively[1].

IC50 & Target[1]

EGFR (L858R/T790M/C797S)

0.52 nM (IC50)

EGFR (d746-750/T790M/C779S)

<0.3 nM (IC50)

EGFR (d746-750/C797S)

0.5 nM (IC50)

EGFR (WT)

0.92 nM (IC50)

分子量

514.58

Formula

C30H26N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-125 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-1252472802-77-8EGFREpidermal growth factor receptorErbB-1HER1EGFR inhibitorEGFR (d746-750/T790M/C779S)EGFR (L858R/T790M/C797S)EGFR (d746-750/C797S)EGFR (L858R/C797S)Inhibitorinhibitorinhibit

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