2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-106

EGFR-IN-106 (compound 6) 是一种有效的 EGFR 抑制剂，IC50 值为 0.2396 µM。EGFR-IN-106 显示出细胞毒性和抗炎活性。

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EGFR-IN-106 Chemical Structure

EGFR-IN-106 Chemical Structure

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EGFR-IN-106 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-106 (compound 6) is a potentEGFR inhibitor with an IC50 value of 0.2396 µM. EGFR-IN-106 shows cytotoxic and anti-inflammatory activity[1]。

IC50 & Target[1]

EGFR

0.2396 μM (IC50)

体外研究
(In Vitro)

EGFR-IN-106 (compound 6) (0-100 µM; 24 h) 对 AGS、A-431、MCF-7、MDA-MB-231、HaCaT 细胞具有细胞毒性，IC50 值分别为 3.64、0.034、2.67、10.51、>100 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-106 相关抗体:

Cell Viability Assay[1]

Cell Line: AGS, A-431, MCF-7, MDA-MB-231, HaCaT cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited cell viability with IC50s of 3.64, 0.034, 2.67, 10.51, >100 µM for AGS, A-431, MCF-7, MDA-MB-231, HaCaT cells, respectively.
分子量

434.53

Formula

C24H30N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-106 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-106EGFREpidermal growth factor receptorErbB-1HER1Cytotoxicanti-tumoranti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
EGFR-IN-106
目录号：
HY-162323
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