2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Apoptosis EGFR FAK
  4. EGFR-IN-46

EGFR-IN-46 是一种有效的 EGFR 和 FAK 双重抑制剂，IC50s 分别为 20.17 nM，14.25 nM。EGFR-IN-46 显著抑制癌细胞的生长。EGFR-IN-46 诱导细胞凋亡 (apoptosis)sup>[1]。

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EGFR-IN-46 Chemical Structure

EGFR-IN-46 Chemical Structure

CAS No. : 2764772-88-3

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EGFR-IN-46 相关抗体

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查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1].

IC50 & Target[1]

EGFR

20.17 nM (IC50)

FAK

14.25 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 µM, respectively[1].
EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells[1].
EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-46 相关抗体:

Cell Proliferation Assay[1]

Cell Line: DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89.34%, 84.76%, 90.36%, 90.78% for DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells, respectively.

Apoptosis Analysis[1]

Cell Line: DLD1 cells
Concentration: 3 µM
Incubation Time: 24 h
Result: Increased the total percentage of apoptotic cells from 7% to 90.33%.
分子量

503.56

Formula

C27H32F3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-46 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

EGFR-IN-462764772-88-3ApoptosisEGFRFAKEpidermal growth factor receptorErbB-1HER1PTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseAnticancerapoptosisDLD1 cellsTOP1anti-prolifreationquinolineInhibitorinhibitorinhibit

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