2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR/HER2-IN-15

EGFR/HER2-IN-15 是一种二氢嘧啶，是一种有效的 EGFR/HER2 抑制剂。EGFR/HER2-IN-15 显著抑制 EGFRwt 活性，IC50 为 37.21 nM。EGFR/HER2-IN-15 具有抗癌作用。

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EGFR/HER2-IN-15 Chemical Structure

EGFR/HER2-IN-15 Chemical Structure

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EGFR/HER2-IN-15 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/HER2-IN-15, a dihydropyrimidine, is a potent EGFR/HER2 inhibitor. EGFR/HER2-IN-15 significantly inhibits EGFRwt activity with an IC50 of 37.21 nM. EGFR/HER2-IN-15 has anticaner effects[1].

IC50 & Target[1]

EGFR (WT)

37.21 nM (IC50)

体外研究
(In Vitro)

浓度为 1000 nM 时，EGFR/HER2-IN-15（化合物 21）对 EGFR 和 HER2 表达的抑制率分别为 98.51% 和 96.79%[1]。
EGFR/HER2-IN-15 抑制 MCF-7 乳腺癌细胞，IC50 为 9.38 μM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR/HER2-IN-15 相关抗体:
分子量

503.55

Formula

C28H29N3O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR/HER2-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-15EGFREpidermal growth factor receptorErbB-1HER1EGFR/HER2 inhibitordihydropyrimidineanticaner effectsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162623
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