2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR ligand-2

EGFR ligand-2 (compound C4) 是一种共价 EGFR 配体，是一种 EGFR 突变抑制剂，对 EGFRL858R 和 EGFRL858R/T790M 的 IC50 分别为 21 nM 和 48 nM。EGFR ligand-2 可用于合成 PROTAC。

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EGFR ligand-2 Chemical Structure

EGFR ligand-2 Chemical Structure

CAS No. : 2737283-20-2

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EGFR ligand-2 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL858R and EGFRL858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC[1].

IC50 & Target[1]

EGFRL858R

21 nM (IC50)

EGFRL858R/T790M

48 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
7090 nM
Compound: C4
Antiproliferative activity against human A-431 cells expressing EGFR wildtype assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells expressing EGFR wildtype assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 35254067]
HCC827 IC50
0.33 nM
Compound: C4
Antiproliferative activity against human HCC827 cells expressing EGFR deletion19 mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells expressing EGFR deletion19 mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 35254067]
NCI-H1975 IC50
12 nM
Compound: C4
Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 35254067]
分子量

537.66

Formula

C30H35N9O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR ligand-2 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR ligand-22737283-20-2EGFR ligand2EGFR ligand 2EGFREpidermal growth factor receptorErbB-1HER1EGFR ligandEGFR mutantPROTACInhibitorinhibitorinhibit

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