2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. JBJ-07-149

JBJ-07-149 是 EGFRL858R/T790M 的抑制剂，IC50 为 1.1 nM。JBJ-07-149 抑制 Ba/F3 细胞增殖，在没有和有 Cetuximab (HY-P9905) 联合使用的情况下，IC50 分别为 4.9 μM 和 0.148 μM。JBJ-07-149 可以作为靶蛋白配体用于合成 DDC-01-163 (HY-139997)。

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JBJ-07-149 Chemical Structure

JBJ-07-149 Chemical Structure

CAS No. : 2140807-58-3

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JBJ-07-149 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JBJ-07-149 is an inhibitor for EGFRL858R/T790M with an IC50 of 1.1 nM. JBJ-07-149 inhibits the proliferation of cell Ba/F3 with IC50 of 4.9 μM and 0.148 μM, without and with presence of Cetuximab (HY-P9905). JBJ-07-149 can be used as ligand for target protein in synthesis of DDC-01-163 (HY-139997)[1].

IC50 & Target

EGFRL858R/T790M

1.1 nM (IC50)

分子量

510.61

Formula

C28H26N6O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JBJ-07-149 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBJ-07-1492140807-58-3EGFREpidermal growth factor receptorErbB-1HER1Ba/F3Inhibitorinhibitorinhibit

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产品名称：
JBJ-07-149
目录号：
HY-151048
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