2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR kinase inhibitor 3

EGFR kinase inhibitor 3 (compound 2) 是一种二价 ATP-变构 EGFR 激酶抑制剂，对于 WT EGFR、EGFR 激活突变 L858R、L858R/T790M 和 L858R/T790M/C797S 的 IC50 分别为 <10 nM、1.5 nM、0.059 nM、0.064 nM。EGFR kinase inhibitor 3 是一种 C 连接抑制剂。

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EGFR kinase inhibitor 3 Chemical Structure

EGFR kinase inhibitor 3 Chemical Structure

CAS No. : 2922402-03-5

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规格 价格 是否有货 数量
1 mg ￥3920
1 - 3 周
5 mg 现货 1 - 3 周
10 mg   询价  
50 mg   询价  

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EGFR kinase inhibitor 3 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor[1].

IC50 & Target[1]

EGFR (WT)

<10 nM (IC50)

EGFR L858R

1.5 nM (IC50)

EGFR L858R/T790M

0.059 nM (IC50)

EGFR L858R/T790M/C797S

0.064 nM (IC50)

分子量

575.64

Formula

C31H25N7O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR kinase inhibitor 3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR kinase inhibitor 32922402-03-5EGFR kinase inhibitor3EGFR kinase inhibitor-3EGFREpidermal growth factor receptorErbB-1HER1BivalentATP-allostericL858RT790MC797SC-linkedInhibitorinhibitorinhibit

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