2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. EGFR Ras Phosphatase
  4. Tyrphostin 8

Tyrphostin 8 是一种酪氨酸激酶，抑制 EGFR 激酶的 IC50 值为 560 μM。Tyrphostin 8 也是一种 GTPase 抑制剂。Tyrphostin 8 可以抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM)。

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Tyrphostin 8 Chemical Structure

Tyrphostin 8 Chemical Structure

CAS No. : 3785-90-8

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规格 价格 是否有货 数量
1 mg ￥141
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5 mg ￥280
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10 mg ￥399
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25 mg ￥666
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50 mg ￥978
In-stock
100 mg ￥1438
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Tyrphostin 8 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM)[1][2][3].

IC50 & Target[1][3]

EGFR

560 μM (IC50)

calcineuin phosphatase

21 μM (IC50)

体外研究
(In Vitro)

Tyrphostin 8 (10-100 μM; pretreated for 20 min) blocks the Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells[1].
Tyrphostin 8 (10-100 μM) produces a rapid and large increase in the basal O2 consumption of parotid acinar[1].
Tyrphostin 8 (10-100 μM) reduces the parotid ATP content by ∼90% at the concentration of 100 μM[1].
Tyrphostin 8 increases apical-to-basolateral transport of insulin-transferrin conjugate by enhancing transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrphostin 8 相关抗体:

Western Blot Analysis[1]

Cell Line: Parotid acinar cells
Concentration: 10, 100 μM
Incubation Time: Pretreated for 20 min
Result: Reduced the increase in tyrosine phosphorylation of PKCδ initiated by carbachol.
Reduced the activation of ERK1/2 by carbachol.
体内研究
(In Vivo)

Tyrphostin 8 improves the glucose-lowering effect of Insulin-transferrin in Streptozotocin-induced diabetic rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

170.17

Formula

C10H6N2O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (587.65 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.8765 mL 29.3824 mL 58.7648 mL
5 mM 1.1753 mL 5.8765 mL 11.7530 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (283 KB) HNMR (106 KB) LCMS (239 KB)

产品使用指南 (1538 KB)
参考文献

Tyrphostin 8 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8765 mL 29.3824 mL 58.7648 mL 146.9119 mL
5 mM 1.1753 mL 5.8765 mL 11.7530 mL 29.3824 mL
10 mM 0.5876 mL 2.9382 mL 5.8765 mL 14.6912 mL
15 mM 0.3918 mL 1.9588 mL 3.9177 mL 9.7941 mL
20 mM 0.2938 mL 1.4691 mL 2.9382 mL 7.3456 mL
25 mM 0.2351 mL 1.1753 mL 2.3506 mL 5.8765 mL
30 mM 0.1959 mL 0.9794 mL 1.9588 mL 4.8971 mL
40 mM 0.1469 mL 0.7346 mL 1.4691 mL 3.6728 mL
50 mM 0.1175 mL 0.5876 mL 1.1753 mL 2.9382 mL
60 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4485 mL
80 mM 0.0735 mL 0.3673 mL 0.7346 mL 1.8364 mL
100 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4691 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrphostin 83785-90-8Tyrphostin8Tyrphostin-8EGFRRasPhosphataseEpidermal growth factor receptorErbB-1HER1tyrosineGTPaseserinethreoninecalcineurinInhibitorinhibitorinhibit

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