2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-132

EGFR-IN-132 (Compound 23) 是 EGFR 抑制剂，可抑制 EGFR 野生型、L858R/T790M、d19/T790M、L858R/T790M/C797S 和 d19/T790M/C797S 突变体，IC50 分别为 1.6、0.025、0.019、0.022 和 0.029 nM。EGFR-IN-132 具有良好的药代动力学特性，口服暴露度高。

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EGFR-IN-132 Chemical Structure

EGFR-IN-132 Chemical Structure

CAS No. : 2809982-20-3

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EGFR-IN-132 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure[1].

IC50 & Target

EGFR (WT)

1.6 nM (IC50)

分子量

501.58

Formula

C27H31N7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-132 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-1322809982-20-3EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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