2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Gancotamab

Gancotamab  (Synonyms: 甘妥单抗; MM-302)

目录号: HY-P99630

摩尔计算器

Gancotamab (MM-302) 是一种 HER2 靶向抗体-脂质体 Doxorubicin 偶联物，具有抗肿瘤活性。Gancotamab 封装 Doxorubicin 以促进其递送至 HER2 过表达肿瘤细胞。

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CAS No. : 1509928-00-0

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Gancotamab 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gancotamab (MM-302) is a HER2-targeted antibody-liposomal Doxorubicin conjugate with antitumor activity. Gancotamab encapsulates Doxorubicin to facilitate its delivery to HER2-overexpressing tumor cells[1].

同型

scFv-heavy-lambda
种属

Human
IC50 & Target[1]

HER2

 

体外研究
(In Vitro)

Gancotamab（MM-302；0.5 μM；72 小时）增加 BT474-M3 和 NCI-N87 细胞的细胞死亡[1]。
Gancotamab（MM-302；1 μM；2-24 小时）在 BT474-M3 和 NCI-N87 细胞中激活 p-p53 水平，对 p-Akt 信号没有影响[1]。< br/> Gancotamab (MM-302) 是一种靶向 HER2 的脂质体，其核心包裹着大约 20,000 个 Doxorubicin 分子，其表面结合了 45 个单链抗 HER2 抗体 (scFv)[1]。 BT474-M3 and NCI-N87 cells

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gancotamab 相关抗体:

Cell Viability Assay[1]

Cell Line: BT474-M3 and NCI-N87 cells
Concentration: 0.5 μM
Incubation Time: 72 hours
Result: Significantly reduced in vitro viability.

Western Blot Analysis[1]

Cell Line: BT474-M3 and NCI-N87 cells
Concentration: 1 μM
Incubation Time: 2 h, 8 h, and 24 h
Result: Increased the p-p53 level and had no effect on p-Akt signal.
体内研究
(In Vivo)

Gancotamab（MM-302；3 mg/kg；静脉注射；每 7 天一次；共 3 剂）表现出肿瘤生长抑制作用并增加 DNA 损伤标记物 p-p53 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old female NCR/nu mice injected with NCI-N87 cells[1]
Dosage: 3 mg/kg
Administration: i.v.; every 7 days; for 3 doses
Result: Showed significantly antitumor activity.
Clinical Trial
CAS 号
中文名称

甘妥单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • scFv-heavy-lambda
纯度 & 产品资料
参考文献

Gancotamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gancotamab1509928-00-0MM-302甘妥单抗MM302MM 302EGFREpidermal growth factor receptorErbB-1HER1DNA damageantitumor activityp-p53DoxorubicinHER2-positive metastatic breast cancerInhibitorinhibitorinhibit

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