2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. Topoisomerase EGFR CDK Apoptosis
  4. EGFR-IN-45

EGFR-IN-45 是一种有效的表皮生长因子受体 (EGFR) 泛抑制剂，对 EGFR 和 CDK2 的 IC50 分别为 0.4 µM 和 1.6 µM。EGFR-IN-45 也抑制拓扑异构酶 Topo I 和 Topo II。EGFR-IN-45 能将癌细胞抑制在 G1 前期，诱导细胞凋亡 (apoptosis)。

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EGFR-IN-45 Chemical Structure

EGFR-IN-45 Chemical Structure

CAS No. : 2765560-03-8

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EGFR-IN-45 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].

IC50 & Target[1]

CDK2

1.6 μM (IC50)

EGFR

0.4 μM (IC50)

体外研究
(In Vitro)

EGFR-IN-45 (compound 30b) (0-10 μM; 48 hours) exhibits the high anticancer activity against Panc-1, MCF-7, HT-29 and A-549[1].
EGFR-IN-45 (20 and 100 μM; hours) can inhibit Topo I and Topo II in a dose-dependent manner[1].
EGFR-IN-45 (0-8 μM; 24 hours) has a high percentage of cell accumulation in the pre-G1 phase in MCF-7[1].
EGFR-IN-45 (0-8 μM; 24 hours) induces high amounts of apoptosis, with a necrosis percent of 2.99[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-45 相关抗体:

Cell Proliferation Assay

Cell Line: Panc-1, MCF-7, HT-29 and A-549[1]
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Exhibited the high anticancer activity with IC50s of 0.9±0.20, 0.8±0.5, 1.3±0.3, 1.2±0.2 μM in Panc-1, MCF-7, HT-29 and A-549, respectively.

Cell Cycle Analysis

Cell Line: MCF-7[1]
Concentration: 0, 2, 4, 6 and 8 μM
Incubation Time: 24 hours
Result: Showed a high percentage of cell accumulation (36.02%) in the pre-G1 phase in MCF-7.

Apoptosis Analysis

Cell Line: MCF-7[1]
Concentration: 0, 2, 4, 6 and 8 μM
Incubation Time: 24 hours
Result: Induced high amounts of apoptosis, with a necrosis percent of 2.99.
分子量

473.53

Formula

C28H23N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-45 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

EGFR-IN-452765560-03-8TopoisomeraseEGFRCDKApoptosisEpidermal growth factor receptorErbB-1HER1Cyclin dependent kinaseAnticancerCell proliferationCell cycleMCF-7Inhibitorinhibitorinhibit

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