CDK11

Cyclin-dependent kinase 11 (CDK11) binds to L-type cyclins and participates in the coordination between transcription and RNA processing, particularly alternative splicing. CDK11 also plays a crucial role in cancer cell proliferation and growth.The functions of CDK11 have been proved to be linked with RNA transcription and processing, regulation of cell cycle, neuronal function, and apoptosis. The potential for CDK11 to regulate these diverse cellular activities is unique in the CDK family and highlights that CDK11 may exert critical regulatory roles in human tumorigenesis and malignant characteristics of cancer cells.