2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling Cell Cycle/DNA Damage Epigenetics MAPK/ERK Pathway
  3. RET EGFR Aurora Kinase c-Fms MAP4K
  4. RET-IN-19

RET-IN-19 (compound 59) 是一种有效的 RET 抑制剂，对 RET-wt 和 RET V804M 的 IC50 值分别为 6.8 和 13.51 nM。RET-IN-19 具有抗癌活性。RET-IN-19 可用于非小细胞肺癌 (NSCLC) 研究。

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RET-IN-19 Chemical Structure

RET-IN-19 Chemical Structure

CAS No. : 2484919-71-1

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RET-IN-19 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research[1].

IC50 & Target

EGFR

56.78 ± 4. μM (IC50)

Aurora A

0.242 ± 0. μM (IC50)

Aurora B

0.536 ± 45 μM (IC50)

MAP4K4

3.428 ± 0. μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LC-2-ad GI50
0.1067 μM
Compound: 59
Growth inhibition of human LC-2-ad cells measured after 3 days by resazurin staining based fluorescence assay
Growth inhibition of human LC-2-ad cells measured after 3 days by resazurin staining based fluorescence assay
[PMID: 32823007]
体外研究
(In Vitro)

RET-IN-19 (compound 59) shows growth inhibition of LC-2/ad cells which RET-CCDC6 driven, with a GI50 of 0.1067 ± 0.004 μM[1].
RET-IN-19 (3 μM) shows inhibition of LC-2/ad cells migration[1].
RET-IN-19 inhibits EGFR, Aurora A, Aurora B, Nek2, CSF-1R, MAP4K4, NIK, and RET, with IC50 values of 56.78 ± 4.94, 0.242 ± 0.036, 0.536 ± 45.12, >200, 1.65 ± 0.235, 3.428 ± 0.150, >10, and 0.0068 ± 0.0003, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RET-IN-19 相关抗体:
分子量

544.62

Formula

C28H28N6O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RET-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-192484919-71-1RETEGFRAurora Kinasec-FmsMAP4KEpidermal growth factor receptorErbB-1HER1CSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RMAPK Kinase Kinase KinaseAnticancerNon-small cell lung cancerNSCLCLC-2/ad cellsInhibitorinhibitorinhibit

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