2. GPCR/G Protein
  3. Adenosine Receptor
  4. PSB-10 hydrochloride

PSB-10 hydrochloride 是一种有效的选择性人腺苷 A3 受体 (A3AR) 拮抗剂，Ki 值为 0.44 nM。PSB-10 hydrochloride 显示出对 hA3AR 受体比对 rA1，rA2A，hA1，hA2A 和 hA2B 受体 (Ki=805, 6040, 1700, 2700, 30000 nM) 超出 800 倍的选择性。PSB-10 hydrochloride 在小鼠中产生热痛觉过敏。

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PSB-10 hydrochloride Chemical Structure

PSB-10 hydrochloride Chemical Structure

CAS No. : 591771-91-4

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规格 价格 是否有货 数量
5 mg ￥3562
3 - 4 周
10 mg ￥5702
3 - 4 周
50 mg   询价  
100 mg   询价  

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PSB-10 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2].

IC50 & Target

Ki: 0.44 nM (hA3AR)[2]
体外研究
(In Vitro)

PSB-10 hydrochloride exhibits a subnanomolar Ki value (Ki=0.43 nM versus [3H]NECA) for A3AR. In addition, R-8 is highly selective (>800-fold) versus the other AR subtypes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSB-10 hydrochloride 相关抗体:
体内研究
(In Vivo)

PSB-10 hydrochloride (50-100 mg/kg; i.p.) dose-dependently decreases hot-plate response latencies in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

435.14

Formula

C16H15Cl4N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSB-10 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-10591771-91-4PSB10PSB 10Adenosine ReceptorP1 receptoradenosineA3thermalhyperalgesiaInhibitorinhibitorinhibit

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产品名称：
PSB-10 hydrochloride
目录号：
HY-103177
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