Adenosine Receptor Inhibitors

A₁AR

A_2AR

A2AR, Ki: 1.4 nM

A2AR

A2BR

A1R, Ki: 1 nM

A2AR, Ki: 398 nM

Adenosine A₃ receptor, Ki: 200 nM

hA₃, Ki: 1.65 nM

A2BR

A₁AR

Adenosine A₃ receptor

A₁AR

A2AR

A2BR

A2AR, Ki: 46 nM (human)

rA₁, Ki: 0.12 nM

rA_2A, Ki: 552 nM

hA_2B, Ki: 187 nM

hA₃, Ki: 2300 nM
rA₃, Ki: 6500 nM

A2AR

A2a adenosine receptor, IC₅₀: 1 nM
A2b adenosine receptor, IC₅₀: 3 nM

A1R, Ki: 6.6 nM

A_2AR, Ki: 5400 nM

Recombinant Human Adenosine A³ receptor (A³R) , Ki: 4.03 nM

rA₁, Ki: >100 nM

rA_2A, Ki: >100 nM

hA₃, Ki: 2.69 nM

A2AR

A1R, Ki: 2.6 nM

A2AR, Ki: 28 nM

A2BR, EC₅₀: 12 nM

hA_2B, Ki: 3.49 nM

A₁AR, Ki: >1000 nM

A2AR, Ki: 68.5 nM

hA_2B, Ki: >1000 nM

Adenosine A₃ receptor, Ki: >1000 nM

hA₁AR, pKi: 6.11

hA_2AAR, pKi: <4

A2AR, IC₅₀: 29 nM

hA₁AR, pKi: 6.29

hA_2AAR, pKi: <4

hA₁AR, Ki: 4.819 μM

hA_2AAR, Ki: 6.4 nM

hA₃, Ki: >30 μM

A2AR, IC₅₀: 0.29 nM

human A1, Ki: 36.7 nM
rat A1, Ki: 1.47 nM

human A3, Ki: 25.4 nM

Adenosine A₃ receptor

hA₁AR, Ki: 2.22 μM

hA_2AAR, Ki: 7.73 μM

hA₃, Ki: 37 nM

hA₃, Ki: 4.63 nM

A2AR, IC₅₀: 11.2 nM

A2BR, IC₅₀: 6.4 nM

A₁AR, Ki: 52.2 ± 8.5 nM

A2AR, Ki: 167 ± 22 nM

hA_2B, Ki: >1000 nM

Adenosine A₃ receptor, Ki: >1000 nM

hA_2AAR, Ki: 90 nM

hA₃, Ki: 31.8 nM

human A3, Ki: 1.24 nM

A1R

A1R, Ki: 107 nM

A2AR, Ki: 0.4 nM

A2BR, Ki: 37 nM

A3R, Ki: 1467 nM

rA₁, Ki: 7.0 nM

rA_2A, Ki: 2.5 nM

A2BR, Ki: 61.8 nM

rA₃, Ki: >1000 nM

A2a adenosine receptor, IC₅₀: 33.5 nM

Adenosine A₃ receptor

Adenosine A₃ receptor, Ki: ~3 nM

human A3, Ki: 12 nM

A1, Ki: >1000 nM

A_2A, Ki: >2500 nM

A_2B, Ki: 17 nM

A3, Ki: >1000 nM

hA₁AR, pKi: 7.13

hA_2AAR, pKi: <4

A1R

A2AR, Ki: 18.3 nM

human A3, Ki: 2.3 nM

hA₃, Ki: 4.54 nM

hA_2AAR, Ki: 0.6 nM
rA_2A, Ki: 0.9 nM

A₁AR, Ki: 503.3 ± 14 nM

A2AR, Ki: 163.5 ± 14 nM

hA_2B, Ki: >10000 nM

Adenosine A₃ receptor, Ki: >10000 nM

Adenosine A₃ receptor

Adenosine A₃ receptor, Ki: 2.40 nM

human A1, Ki: 9.69 nM
rat A1, Ki: 0.529 nM

A1R

A2a adenosine receptor

A2AR, IC₅₀: 8.3 nM

A₁AR

human A1, Ki: 14 nM

human A3, Ki: 0.017 nM

hA₁AR, Ki: 4.6 μM

hA_2AAR, Ki: 4.8 μM

A1, Ki: 0.3 μM

A_2A, Ki: 0.08 μM

A_2B, Ki: 25.5 μM

A3, Ki: 1.9 μM

Adenosine A₃ receptor

A2AR

A1, Ki: 167 nM

hA₃, Ki: 6.7 nM

A2a adenosine receptor

A_2A, Ki: 0.49 μM

A_2B, Ki: 10 μM

A₁, Ki: >10,000 nM

A_2A, Ki: >5,000 nM

A_2B, Ki: 50 nM