2. GPCR/G Protein
  3. Adenosine Receptor
  4. MRS3558

MRS3558 是一种强效且有选择性的 A3AR 激动剂，对人和大鼠的 Ki 分别为 0.6 和 0.9 nM，可用于神经疼痛及麻醉领域研究。

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MRS3558 Chemical Structure

MRS3558 Chemical Structure

CAS No. : 793695-40-6

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MRS3558 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRS3558 is a potent and selective A3AR agonist, with Ki values of 0.6 nM for humans and 0.9 nM for rats, making it suitable for research in the fields of neuropathic pain and anesthesia[1].

IC50 & Target

hA2AAR

0.6 nM (Ki)

rA2A

0.9 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
3.26 μM
Compound: 35
Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay
Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay
[PMID: 27933810]
分子量

463.32

Formula

C20H20Cl2N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRS3558 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS3558793695-40-6MRS 3558MRS-3558Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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产品名称：
MRS3558
目录号：
HY-122231
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