2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine receptor inhibitor 1

Adenosine receptor inhibitor 1 

目录号: HY-147907
产品使用指南

摩尔计算器

Adenosine receptor inhibitor 1 是一种有效的选择性腺苷受体 (adenosine receptor (AR)) 抑制剂，A1AR、A2AAR、A2BAR、A3AR 的 Ki 值 分别为 >1000, 68.5, >1000, >1000 nM。Adenosine receptor inhibitor 1 显示出镇痛活性、抗炎作用和外周镇痛作用。Adenosine receptor inhibitor 1具有研究癌症或神经退行性疾病的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Adenosine receptor inhibitor 1 Chemical Structure

Adenosine receptor inhibitor 1 Chemical Structure

CAS No. : 2550400-52-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2400
5 - 7 周
5 mg ￥5450
5 - 7 周
10 mg 现货 5 - 7 周
25 mg 现货 5 - 7 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Adenosine receptor inhibitor 1 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adenosine receptor inhibitor 1 is a potent and selective adenosine receptor (AR) inhibitor with Ki values of >1000, 68.5, >1000, >1000 nM for A1AR, A2AAR, A2BAR, A3AR, respectively. Adenosine receptor inhibitor 1 shows antinociceptive activity, anti-inflammatory effect and peripheral analgesic effect. Adenosine receptor inhibitor 1 has the potential for the research of cancer or neurodegenerative diseases[1].

IC50 & Target[1]

A1AR

>1000 nM (Ki)

A2AR

68.5 nM (Ki)

hA2B

>1000 nM (Ki)

Adenosine A3 receptor

>1000 nM (Ki)

体外研究
(In Vitro)

Adenosine receptor inhibitor 1 (compound 12d) (120 min) shows metabolic stability incubated with with 96.56 and 97.97% of the parent compound remained in the reaction mixtures after incubation with mouse (MLMs) and rat liver microsomes (RLMs), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Adenosine receptor inhibitor 1 相关抗体:
体内研究
(In Vivo)

Adenosine receptor inhibitor 1 (20, 30, 40 mg/kg; i.p.) shows antinociceptive activity at a concentration-dependent mannner[1].
Adenosine receptor inhibitor 1 (20 mg/kg; i.p.) shows anti-inflammatory effect in carrageenan-induced edema model[1].
Adenosine receptor inhibitor 1 (5, 10, 20 mg/kg; i.p.) shows analgesic effect in mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-26 g male albino Swiss mice (chronic pain induced by the administration of 5% formalin) [1]
Dosage: 20, 30, 40 mg/kg
Administration: I.p.
Result: Showed antinociceptive activity with decreasesed the licking/biting time of the right hind paw of mice in response to the irritating chemical stimulus.
Animal Model: 150-180 g male rats Wistar(carrageenan-induced edema model)[1]
Dosage: 20 mg/kg
Administration: I.p.
Result: Showed anti-inflammatory effect with the inhibition of 23.3%, 54.2%, 66.0% at 1h, 2h, 3h, respectively.
Animal Model: Mouse (induce pain of peripheral origin by injection of an irritant like phenylbenzoquinone or acetic acid in mice)[1]
Dosage: 5, 10, 20 mg/kg
Administration: I.p.
Result: Showed peripheral analgesic effect with the significant decrease in the number of writhings by 32.9%, 54.9%, 82.0% at doses of 5, 10, 20 mg/kg, respectively.
分子量

395.82

Formula

C17H19ClFN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Adenosine receptor inhibitor 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine receptor inhibitor 12550400-52-5Adenosine receptor inhibitor1Adenosine receptor inhibitor-1Adenosine ReceptorP1 receptorliver microsomesantinociceptive activityanti-inflammatory effectanalgesic effectedema modelInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Adenosine receptor inhibitor 1
目录号：
HY-147907
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z