2. Protein Tyrosine Kinase/RTK Apoptosis PROTAC
  3. FLT3 Apoptosis Ligands for Target Protein for PROTAC
  4. Quizartinib dihydrochloride

Quizartinib dihydrochloride  (Synonyms: AC220 dihydrochloride)

目录号: HY-14217 纯度: 99.81%
COA 产品使用指南

摩尔计算器

Quizartinib dihydrochloride (AC220 dihydrochloride) 是 Quizartinib (HY-13001) 的二盐酸盐形式。Quizartinib dihydrochloride 是一种具有口服活性的、高选择性的，有效的第二代 Ⅱ 型 FLT3 (type II FLT3) 酪氨酸激酶抑制剂，Kd 值为 1.6 nM。Quizartinib dihydrochloride 抑制 Wt FLT3 和 突变型 FLT3-ITD 自磷酸化，IC50 分别为 4.1 nM 和 1.1 nM。Quizartinib dihydrochloride 可以通过优化的 linker 与 VHL 配体连接，从而形成 PROTAC Flt3 降解剂。Quizartinib dihydrochloride 诱导细胞凋亡 (apoptosis)。

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Quizartinib dihydrochloride Chemical Structure

Quizartinib dihydrochloride Chemical Structure

CAS No. : 1132827-21-4

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规格 价格 是否有货 数量
5 mg ￥900
In-stock
10 mg ￥1450
In-stock
25 mg ￥2600
In-stock
50 mg ￥4200
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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Other Forms of Quizartinib dihydrochloride:

Quizartinib dihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 31 篇科研文献

WB

    Quizartinib dihydrochloride purchased from MCE. Usage Cited in: J Med Chem. 2017 Oct 26;60(20):8407-8424.  [Abstract]

    Doseresponsive immunoblotting of the signaling pathway with the cells extracted from tumor tissues of the experimental animal after the 14 and 7 (AC220) treatments.

    Quizartinib dihydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2016 Jul 26;7(30):47018-47032.  [Abstract]

    A. The established 32D cells are treated with Quizartinib for 2h, followed by 10 ng/mL FL stimulation for 10 minutes. Wt-FLT3 and mutant FLT3 are immunoprecipitated by each tag as indicated and subjected to Western blot. Phosphorylation levels of FLT3, STAT5, AKT and MAPK are examined. B. 32D cells are treated with Quizartinib at the indicated concentrations in the presence or absence of 10 ng/mL FL for 2 hours. Phosphorylation levels of FLT3, STAT5, AKT and MAPK are detected by Western blot.

    Quizartinib dihydrochloride purchased from MCE. Usage Cited in: Cancer Cell. 2014 Feb 10;25(2):226-42.  [Abstract]

    Western blot for indicated proteins on lysates from FLT3-ITD-positive primary murine cells expressing either wild-type (WT) or constitutive active (SYK-TEL) SYK and treated for eight hours with indicated doses of AC220.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib (HY-13001). Quizartinib dihydrochloride is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib dihydrochloride inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib dihydrochloride can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib dihydrochloride induces apoptosis[1][2][3].

    分子量

    633.59

    Formula

    C29H34Cl2N6O4S
    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 33.33 mg/mL (52.60 mM; ultrasonic and adjust pH to 12 with 1 M NaOH; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.5783 mL 7.8915 mL 15.7831 mL
    5 mM 0.3157 mL 1.5783 mL 3.1566 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Quizartinib dihydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.5783 mL 7.8915 mL 15.7831 mL 39.4577 mL
    5 mM 0.3157 mL 1.5783 mL 3.1566 mL 7.8915 mL
    10 mM 0.1578 mL 0.7892 mL 1.5783 mL 3.9458 mL
    15 mM 0.1052 mL 0.5261 mL 1.0522 mL 2.6305 mL
    20 mM 0.0789 mL 0.3946 mL 0.7892 mL 1.9729 mL
    25 mM 0.0631 mL 0.3157 mL 0.6313 mL 1.5783 mL
    30 mM 0.0526 mL 0.2631 mL 0.5261 mL 1.3153 mL
    40 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9864 mL
    50 mM 0.0316 mL 0.1578 mL 0.3157 mL 0.7892 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Quizartinib1132827-21-4AC220AC 220AC-220FLT3ApoptosisLigands for Target Protein for PROTACCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Target Protein-binding MoietyoralselectiveAMLacutemyeloidleukemiaFLT3-ITDmutationInhibitorinhibitorinhibit

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