2. Immunology/Inflammation
  3. Toll-like Receptor (TLR) Interleukin Related NOD-like Receptor (NLR)
  4. RC529-MDP

RC529-MDP 是 Toll 样受体 (TLR) (TLR4a) 和 NOD 样受体 (NOD2a) 相偶联得到的免疫佐剂，增强了先天免疫应答，其活性依赖于 TLR4 和 NOD2 信号通路。RC529-MDP 在小鼠模型中诱导了高水平的细胞因子 白细胞介素相关因子 (IL-6)，具有免疫刺激活性。RC529-MDP 在注射 OVA (HY-P0286) 小鼠模型中提高了 OVA 特异性抗体应答，T 细胞应答和记忆 T 细胞比例。

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RC529-MDP Chemical Structure

RC529-MDP Chemical Structure

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     可免费申领三个不同产品的试用装。

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Customer Review

RC529-MDP 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RC529-MDP is an immunoadjuvant, combination of Toll-like Receptor (TLR) (TLR4a) and NOD-like Receptor (NOD2a), which enhances innate immune responses. BRC529-MDP activity depends on the TLR4 and NOD2 signaling pathways. RC529-MDP induces high levels of cytokine Interleukin Related (IL-6) in a mouse model, has immune-stimulating activity. RC529-MDP increases OVA-specific antibody responses, T cell responses, and the proportion of memory T cells in an OVA (HY-P0286)-injected mouse model[1].

IC50 & Target

IL-6

 

TLR4

 

NOD2

 

体外研究
(In Vitro)

RC529-MDP (9.3 μM，20 h) 的活性依赖于 TLR4 和 NOD2 信号通路[1]。
RC529-MDP (偶联物) 在 Raw264.7 细胞中 CD80 和 CD86 细胞比例比 RC529 + MDP (混合物) 高 1.7 倍，有效促进抗原呈递细胞 (APC) 的成熟[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RC529-MDP 相关抗体:
体内研究
(In Vivo)

RC529-MDP 偶联物在小鼠体内使 IL-6 水平提高了 6.8 倍，导致了强有力的协同效应[1]。
RC529-MDP (22.53 μg，i.p.) 在小鼠模型中体液免疫增强，同时增强了 IgG 亚型 (IgG1，IgG2a，IgG2b) 的水平[1]。
RC529-MDP (22.53 μg，s.c.) 和 OVA 同时注射的小鼠模型中，适应性体液免疫快速被激活，分泌细胞因子的 T 细胞增多，产生强大的细胞免疫[1]。
RC529-MDP (22.53 μg) 使中枢记忆 T 细胞 (Tcm) 比例增加，产生记忆反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The mice were injected subcutaneously (S.C.) with the RC529-MDP and model antigen ovalbumin (OVA)[1]
Dosage: 22.53 μg
Administration: Subcutaneous injection (s.c.) on days 1, 15, 29
Result: Induced high levels of OVA-specific IgG, and the levels of IgG subtypes were increased.
Induced a 1.3-fold and 3.3-fold increase in the proportion of TNF-α and IFN-γ double-positive secreting CD4+ T and CD8+ T cells compared with RC529 + MDP.
Induced the proportion of central memory T cells (Tcm) of CD8+ and CD4+ cells to increase by 2.7 and 1.2 times compared with RC529 + MDP.
Animal Model: BALB/c mouse[1]
Dosage: 22.53 μg
Administration: Intraperitoneal injection (i.p.)
Result: Bound to RC529-MDP-induced OVA-specific IgG 2.0 times higher than that induced by RC529 + MDP without binding.
分子量

2252.99

Formula

C118H215N10O28P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RC529-MDP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RC529-MDPToll-like Receptor (TLR)Interleukin RelatedNOD-like Receptor (NLR)ILTLR4aNOD2aAPCsOVAThe memory T cellsT cellInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-168010
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