CaMKII beta/CAMK2B 蛋白, Human (sf9, His-GST)

CaMKII beta/CAMK2B, a calcium/calmodulin-dependent protein kinase, autonomously functions after Ca(2+)/calmodulin-binding and autophosphorylation. It plays vital roles in dendritic spine and synapse formation, neuronal plasticity, and the regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, it contributes to actin cytoskeleton reorganization, dendritic arborization, and migration of developing neurons. Additionally, it modulates skeletal muscle function in response to exercise and participates in the JAK-STAT signaling pathway by phosphorylating STAT1. Moreover, it phosphorylates RETREG1, enhancing its reticulophagy activity under endoplasmic reticulum stress conditions. CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is the recombinant human-derived CaMKII beta/CAMK2B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is 503 a.a., with molecular weight of ~85 kDa.

CaMKII beta/CAMK2B 是一种钙/钙调蛋白依赖性蛋白激酶，通过 Ca(2+)/钙调蛋白结合和自磷酸化自主发挥作用，在树突棘和突触形成、神经元可塑性以及肌浆网 Ca 的调节中发挥关键作用。 2+) 骨骼肌运输。在神经元中，该激酶表现出重要的结构功能，通过以激酶独立的方式结合和捆绑肌动蛋白丝，协调可塑性期间肌动蛋白细胞骨架的重组。这种结构作用对于精确靶向 CaMK2A（NMDAR 的下游效应器）、促进树突棘和突触形成以及维持长时程增强 (LTP) 和海马依赖性学习的突触可塑性至关重要。此外，在发育中的海马神经元中，CaMKII beta 促进树突树分枝，而在成熟神经元中，它有助于树突重塑。此外，它还在运动后调节骨骼肌功能中发挥作用，影响肌浆网 (SR) Ca(2+) 转运调节。在慢肌中，它参与调节 SR Ca(2+) 转运，而在快肌中，它通过三联蛋白和受磷蛋白的磷酸化控制 SR 中 Ca(2+) 的释放。响应干扰素-γ (IFN-γ) 刺激，CaMKII beta 催化 STAT1 磷酸化，从而刺激 JAK-STAT 信号通路。此外，在内质网应激条件下，它会使网状自噬调节因子 RETREG1 在“Ser-151”位点磷酸化，从而增强 RETREG1 寡聚化及其膜断裂和网状自噬活性。

Human

Sf9 insect cells

N-His;N-GST

Q13554-3 (M1-Q503)

816  [NCBI]

Approximately 85 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.