2. Gene
  3. CAMK2B - calcium/calmodulin dependent protein kinase II beta Gene

CAMK2B - calcium/calmodulin dependent protein kinase II beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙/钙调蛋白依赖性蛋白激酶 II beta

种属: Homo sapiens

同用名: CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta

基因 ID: 816 | 基因类型: protein coding

关于 CAMK2B

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,217,154-44,326,013 (from NCBI)

This gene has 49 transcripts (splice variants), 255 orthologues, 22 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues.

功能概要

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族和 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族。钙信号对于谷氨酸能突触可塑性的几个方面至关重要。在哺乳动物细胞中，这种酶由四种不同的链组成：α、β、γ 和 δ。该基因的产物是β链。这条链的不同亚型可能具有不同的细胞定位并且与钙调蛋白的相互作用不同。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 5 月]

The product of this gene belongs to the serine/threonine protein kinase family and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the Enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with Calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CAMK2B 基因产物(9)

mRNA Protein Name
NM_001220.5 NP_001211.3 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1
NM_001293170.2 NP_001280099.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2
NM_172078.3 NP_742075.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2
NM_172079.3 NP_742076.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3
NM_172080.3 NP_742077.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4
NM_172081.3 NP_742078.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5
NM_172082.3 NP_742079.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6
NM_172083.3 NP_742080.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7
NM_172084.3 NP_742081.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: 通过直接分析推断
31930741 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
20668654 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
18817731 GOA
involved in regulation of neuron migration IMP
IMP: 通过突变表型推断
29100089 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium- and calmodulin-dependent protein kinase complex IDA
IDA: 通过直接分析推断
20668654 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAMK2B 蛋白结构

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (534 - 661)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type II subunit beta

CaM kinase II beta subunit

CAMK2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CAMK2B Q13554 b3kwq7_human Homo sapiens B3KWQ7
Y2H Array
25416956
种属内
CAMK2B Q13554 b3kwq7_human Homo sapiens B3KWQ7
Validated Y2H
25416956
种属内
CAMK2B Q13554 b3kwq7_human Homo sapiens B3KWQ7
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 KRTAP10-11 Homo sapiens P60412
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
25416956
种属内
CAMK2B Q13554 SPRYD7 Homo sapiens Q5W111
Validated Y2H
25416956
种属内
CAMK2B Q13554 SPRYD7 Homo sapiens Q5W111
Y2H Array
25416956
种属内
CAMK2B Q13554 FAM171A2 Homo sapiens Q8N0U1
Y2H Array
25416956
种属内
CAMK2B Q13554 FAM171A2 Homo sapiens Q8N0U1
Validated Y2H
25416956
种属内
CAMK2B Q13554 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Array
25416956
种属内
CAMK2B Q13554 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 AP5B1 Homo sapiens Q2VPB7
Validated Y2H
25416956
种属内
CAMK2B Q13554 CAMK2B Homo sapiens Q13554
Solution Sedimentation
20668654
种属内
CAMK2B Q13554 AP5B1 Homo sapiens Q2VPB7
Y2H Array
25416956
种属内
CAMK2B Q13554 CAMK2A Homo sapiens Q9UQM7
Anti Tag CoIP
29426014
种属内
CAMK2B Q13554 CAMK2B Homo sapiens Q13554
Y2H Array
25416956
种属内
CAMK2B Q13554 CAMK2D Homo sapiens Q13557
Pull Down
32707033
种属内
CAMK2B Q13554 CAMK2D Homo sapiens Q13557
Anti Tag CoIP
29426014
种属内
CAMK2B Q13554 CAMK2D Homo sapiens Q13557
Solution Sedimentation
20668654
种属内
CAMK2B Q13554 RPL11 Homo sapiens P62913
Validated Y2H
25416956
种属内
CAMK2B Q13554 RPL11 Homo sapiens P62913
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 POP5 Homo sapiens Q969H6
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 MED18 Homo sapiens Q9BUE0
Y2H Array
25416956
种属内
CAMK2B Q13554 MED18 Homo sapiens Q9BUE0
Validated Y2H
25416956
种属内
CAMK2B Q13554 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
种属内
CAMK2B Q13554 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
25416956
种属内
CAMK2B Q13554 RBPMS Homo sapiens Q93062
Y2H Array
25416956
种属内
CAMK2B Q13554 RBFOX2 Homo sapiens O43251
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 RBFOX2 Homo sapiens O43251
Validated Y2H
25416956
种属内
CAMK2B Q13554 RAP2B Homo sapiens P61225
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 RAP2B Homo sapiens P61225
Validated Y2H
25416956
种属内
CAMK2B Q13554 MAD2L2 Homo sapiens Q9UI95
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 SEMA4G Homo sapiens Q9NTN9-3
Y2H Prey Pooling
25416956
种属内
CAMK2B Q13554 ACOT7 Homo sapiens O00154
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CAMK2B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76762 CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) Q13554-3 (M1-Q503) ≥95%

CAMK2B 抗体

目录号 产品名 应用 反应物种
HY-P82599 CaMKII beta Antibody (YA2344) WB Mouse

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 54

Mental Retardation, Autosomal Dominant 54

MRD54

Autosomal Dominant Intellectual Developmental Disorder 54

Autosomal Dominant Mental Retardation 54
Autosomal Dominant Non-Syndromic Intellectual Disability
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes

ASGD5

Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01857 CAMK2B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CAMK2B VGNC VGNC:26722
Rattus norvegicus CAMK2B RGD RGD:2262
Macaca mulatta CAMK2B VGNC VGNC:70524
Mus musculus CAMK2B MGD MGI:88257
Felis catus CAMK2B VGNC VGNC:60332
Others CAMK2B NCBI
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