2. Gene
  3. CAMK2D - calcium/calmodulin dependent protein kinase II delta Gene

CAMK2D - calcium/calmodulin dependent protein kinase II delta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙/钙调蛋白依赖性蛋白激酶 II delta

种属: Homo sapiens

同用名: CAMKD

基因 ID: 817 | 基因类型: protein coding

关于 CAMK2D

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:113,451,032-113,761,738 (from NCBI)

This gene has 38 transcripts (splice variants), 99 orthologues and 22 paralogues. Ubiquitous expression in heart (RPKM 23.1), brain (RPKM 14.9) and 24 other tissues.

功能概要

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族和 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族。钙信号对于谷氨酸能突触可塑性的几个方面至关重要。在哺乳动物细胞中，这种酶由四种不同的链组成：α、β、γ 和 δ。该基因的产物是三角链。可变剪接导致编码不同异构体的多个转录变体。该链的不同异构体具有不同的表达模式。[RefSeq 提供，2008 年 11 月]

The product of this gene belongs to the serine/threonine protein kinase family and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the Enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

CAMK2D 基因产物(48)

mRNA Protein Name
NM_001221.4 NP_001212.2 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3
NM_001321566.2 NP_001308495.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 6
NM_001321567.2 NP_001308496.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 7
NM_001321568.2 NP_001308497.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 8
NM_001321569.2 NP_001308498.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 9
NM_001321570.2 NP_001308499.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 10
NM_001321571.2 NP_001308500.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 11
NM_001321572.2 NP_001308501.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 12
NM_001321573.2 NP_001308502.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 13
NM_001321574.2 NP_001308503.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 14
NM_001321575.2 NP_001308504.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 15
NM_001321576.2 NP_001308505.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 16
NM_001321577.2 NP_001308506.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 17
NM_001321578.2 NP_001308507.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor
NM_001321579.2 NP_001308508.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 19
NM_001321580.2 NP_001308509.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 20
NM_001321581.2 NP_001308510.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 21
NM_001321582.2 NP_001308511.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 22
NM_001321583.2 NP_001308512.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 23
NM_001321584.2 NP_001308513.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 24
NM_001321585.2 NP_001308514.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor
NM_001321586.2 NP_001308515.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 25
NM_001321587.2 NP_001308516.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 26
NM_001321588.2 NP_001308517.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 27
NM_001321589.2 NP_001308518.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5
NM_001321590.2 NP_001308519.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 28
NM_001321591.2 NP_001308520.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 29
NM_001321592.2 NP_001308521.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 30
NM_001396964.1 NP_001383893.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 31
NM_001396965.1 NP_001383894.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 32
NM_001396966.1 NP_001383895.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 33
NM_001396967.1 NP_001383896.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 34
NM_001399855.1 NP_001386784.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 35
NM_001399856.1 NP_001386785.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 36
NM_001399857.1 NP_001386786.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 37
NM_001399858.1 NP_001386787.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 38
NM_001399859.1 NP_001386788.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 39
NM_001399860.1 NP_001386789.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 40
NM_001399861.1 NP_001386790.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 41
NM_001399862.1 NP_001386791.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 42
NM_001399863.1 NP_001386792.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 43
NM_001399864.1 NP_001386793.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 44
NM_001399865.1 NP_001386794.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 45 precursor
NM_172114.2 NP_742112.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5
NM_172115.3 NP_742113.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1
NM_172127.3 NP_742125.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1
NM_172128.3 NP_742126.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2
NM_172129.2 NP_742127.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: 通过直接分析推断
22514276 GOA
enables calmodulin binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
22514276 GOA
enables sodium channel inhibitor activity IDA
IDA: 通过直接分析推断
22514276 GOA
enables titin binding IPI
IPI: 通过物理相互作用推断
23283722 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
22514276 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of sodium ion transmembrane transport IDA
IDA: 通过直接分析推断
22514276 GOA
involved in negative regulation of sodium ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
22514276 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
22514276 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
22514276 GOA
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
17179159 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
22514276 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
17179159 GOA
involved in regulation of cellular localization IMP
IMP: 通过突变表型推断
17179159 GOA
involved in regulation of membrane depolarization IDA
IDA: 通过直接分析推断
22514276 GOA
involved in regulation of relaxation of cardiac muscle IDA
IDA: 通过直接分析推断
23283722 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium- and calmodulin-dependent protein kinase complex IDA
IDA: 通过直接分析推断
20668654 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAMK2D 蛋白结构

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (346 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type II subunit delta

CaM kinase II delta subunit

CAMK2D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CAMK2D Q13557 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
25416956
Intra CAMK2D Q13557 EPHA10 Homo sapiens Q5JZY3-3
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 CAMK2B Homo sapiens Q13554
Anti Tag CoIP
33961781
Intra CAMK2D Q13557 CAMK2B Homo sapiens Q13554
Pull Down
32707033
Intra CAMK2D Q13557 CAMK2G Homo sapiens Q13555
Anti Tag CoIP
33961781
Intra CAMK2D Q13557 CAMK2G Homo sapiens Q13555
Pull Down
32707033
Intra CAMK2D Q13557 CAMK2A Homo sapiens Q9UQM7
Anti Tag CoIP
33961781
Intra CAMK2D Q13557 CAMK2D Homo sapiens Q13557
Y2H Array
31515488
Intra CAMK2D Q13557 CAMK2D Homo sapiens Q13557
Solution Sedimentation
20668654
Intra CAMK2D Q13557 CAMK2D Homo sapiens Q13557
Y2H Array
25416956
Intra CAMK2D Q13557 CAMK2D Homo sapiens Q13557
X-Ray Diffraction
20668654
Intra CAMK2D Q13557 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra CAMK2D Q13557 TNPO2 Homo sapiens O14787
Validated Y2H
25416956
Intra CAMK2D Q13557 TNPO2 Homo sapiens O14787
Y2H Array
25416956
Intra CAMK2D Q13557 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
25416956
Intra CAMK2D Q13557 MRPL11 Homo sapiens Q9Y3B7
Y2H Array
31515488
Intra CAMK2D Q13557 FKBP1B Homo sapiens P68106
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 SCN5A Homo sapiens Q14524
Protein Kinase Assay
22514276
Intra CAMK2D Q13557 SCN5A Homo sapiens Q14524
Anti Bait CoIP
22514276
Intra CAMK2D Q13557 MOAP1 Homo sapiens Q96BY2
Y2H Array
25416956
Intra CAMK2D Q13557 MOAP1 Homo sapiens Q96BY2
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 FXR2 Homo sapiens P51116
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra CAMK2D Q13557 DNAL4 Homo sapiens O96015
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra CAMK2D Q13557 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Y2H Array
31515488
Intra CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Y2H Prey Pooling
25416956
Intra CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Validated Y2H
25416956
Intra CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1dd

Dilated Cardiomyopathy 1dd

CMD1DD

Cardiomyopathy, Dilated 1dd

Cardiomyopathy, Dilated, Type 1dd
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124638 MNK inhibitor 9 Inhibitor / 否
HY-RS01858 CAMK2D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CAMK2D MGD MGI:1341265
Macaca mulatta CAMK2D VGNC VGNC:100206
Bos taurus CAMK2D VGNC VGNC:53692
Rattus norvegicus CAMK2D RGD RGD:2263
Felis catus CAMK2D VGNC VGNC:60333
Canis familiaris CAMK2D VGNC VGNC:57416
Others CAMK2D NCBI
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