2. Gene
  3. MOAP1 - modulator of apoptosis 1 Gene

MOAP1 - modulator of apoptosis 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞凋亡调节因子 1

种属: Homo sapiens

同用名: MAP-1; PNMA4

基因 ID: 64112 | 基因类型: protein coding

关于 MOAP1

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,182,199-93,184,897 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 565 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 65.7), heart (RPKM 21.0) and 24 other tissues.

功能概要

由该基因编码的蛋白质通过其与细胞凋亡调节因子 Bax 蛋白的相互作用来鉴定。该蛋白质包含 Bcl-2 同源性 3 (BH3) 样基序，这是与 Bax 结合所必需的。当过表达时，该基因已被证明可介导半胱天冬酶依赖性细胞凋亡。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was identified by its interaction with Apoptosis regulator Bax protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with Bax. When overexpressed, this gene has been shown to mediate caspase-dependent Apoptosis. [provided by RefSeq, Jul 2008]

MOAP1 基因产物(1)

mRNA Protein Name
NM_022151.5 NP_071434.2 modulator of apoptosis 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11060313 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
19100260 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
11060313 GOA
involved in extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
16199525 GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
16199525 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
16199525 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15949439 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
33783314 GOA
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
16199525 GOA
involved in protein insertion into mitochondrial membrane IMP
IMP: 通过突变表型推断
16199525 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
19100260 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
16199525 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
19100260 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MOAP1 蛋白结构

PNMA

PNMA: PNMA (1 - 326)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
蛋白主名 其他名称

modulator of apoptosis 1

MAP1

MOAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MOAP1 Q96BY2 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra MOAP1 Q96BY2 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
Intra MOAP1 Q96BY2 LATS1 Homo sapiens Q6PJG3
Y2H Array
25416956
Intra MOAP1 Q96BY2 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra MOAP1 Q96BY2 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra MOAP1 Q96BY2 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra MOAP1 Q96BY2 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra MOAP1 Q96BY2 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra MOAP1 Q96BY2 THOC1 Homo sapiens Q96FV9
Validated Y2H
32296183
Intra MOAP1 Q96BY2 THOC1 Homo sapiens Q96FV9
Y2H Prey Pooling
32296183
Intra MOAP1 Q96BY2 THOC1 Homo sapiens Q96FV9
Y2H Array
32296183
Intra MOAP1 Q96BY2 PPP2R3C Homo sapiens Q969Q6
Y2H Prey Pooling
32296183
Intra MOAP1 Q96BY2 PPP2R3C Homo sapiens Q969Q6
Y2H Array
32296183
Intra MOAP1 Q96BY2 CAMK2D Homo sapiens Q13557
Validated Y2H
25416956
Intra MOAP1 Q96BY2 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra MOAP1 Q96BY2 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra MOAP1 Q96BY2 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra MOAP1 Q96BY2 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra MOAP1 Q96BY2 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra MOAP1 Q96BY2 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08572 MOAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MOAP1 MGD MGI:1915555
Rattus norvegicus MOAP1 RGD RGD:1307230
Felis catus MOAP1 VGNC VGNC:104513
Macaca mulatta MOAP1 VGNC VGNC:84392
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